Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4032089..4032708 Replicon chromosome
Accession NZ_CP081893
Organism Klebsiella quasipneumoniae strain WI-06

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ658_RS19520 Protein ID WP_002892050.1
Coordinates 4032490..4032708 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ658_RS19515 Protein ID WP_002892066.1
Coordinates 4032089..4032463 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ658_RS19505 (4027243) 4027243..4028436 + 1194 WP_223065448.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ658_RS19510 (4028459) 4028459..4031605 + 3147 WP_223065449.1 multidrug efflux RND transporter permease subunit AcrB -
KZ658_RS19515 (4032089) 4032089..4032463 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ658_RS19520 (4032490) 4032490..4032708 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ658_RS19525 (4032867) 4032867..4033433 + 567 WP_023288643.1 maltose O-acetyltransferase -
KZ658_RS19530 (4033405) 4033405..4033536 - 132 WP_032428629.1 hypothetical protein -
KZ658_RS19535 (4033570) 4033570..4034040 + 471 WP_023288642.1 YlaC family protein -
KZ658_RS19540 (4034009) 4034009..4035466 - 1458 WP_223065450.1 PLP-dependent aminotransferase family protein -
KZ658_RS19545 (4035567) 4035567..4036265 + 699 WP_223065451.1 GNAT family protein -
KZ658_RS19550 (4036262) 4036262..4036402 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ658_RS19555 (4036402) 4036402..4036665 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213726 WP_002892050.1 NZ_CP081893:4032490-4032708 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213726 NZ_CP109835:278723-279049 [Pseudomonas aeruginosa]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCGCGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213726 WP_002892066.1 NZ_CP081893:4032089-4032463 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213726 NZ_CP109835:278094-278651 [Pseudomonas aeruginosa]
GTGATCTTCAGTGAACAGAAAGTGGCTCACATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCAC
GCTGATCAAACTGCTGTACCTGGCAGACCGAGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTT
CCATGCCCCATGGGCCTGTCCTTTCCTCGACGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGG
ATTTCTCCGTTGGTGGATCACGAGGTCCGTCTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATC
GGATCGCAGCATTTTGGAATCGGTCTGGCAAGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATC
ACATTGGTGAGTGGCACGACCCCCACGGCTCTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGC
GAGGAGCTGGCGGAGATCAAGGCGCGCGATCTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References