Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807857..808514 Replicon chromosome
Accession NZ_CP081893
Organism Klebsiella quasipneumoniae strain WI-06

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag KZ658_RS04035 Protein ID WP_023290968.1
Coordinates 808104..808514 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ658_RS04030 Protein ID WP_002916312.1
Coordinates 807857..808123 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ658_RS04005 (803007) 803007..804440 - 1434 WP_080820269.1 6-phospho-beta-glucosidase -
KZ658_RS04010 (804559) 804559..805287 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
KZ658_RS04015 (805338) 805338..805649 + 312 WP_080820267.1 N(4)-acetylcytidine aminohydrolase -
KZ658_RS04020 (805813) 805813..806472 + 660 WP_008806429.1 hemolysin III family protein -
KZ658_RS04025 (806628) 806628..807611 - 984 WP_060590308.1 tRNA-modifying protein YgfZ -
KZ658_RS04030 (807857) 807857..808123 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ658_RS04035 (808104) 808104..808514 + 411 WP_023290968.1 protein YgfX Toxin
KZ658_RS04040 (808521) 808521..809042 - 522 WP_004205324.1 flavodoxin FldB -
KZ658_RS04045 (809143) 809143..810039 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
KZ658_RS04050 (810062) 810062..810775 + 714 WP_049014195.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ658_RS04055 (810781) 810781..812514 + 1734 WP_080820264.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T213715 WP_023290968.1 NZ_CP081893:808104-808514 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213715 NZ_CP109833:c143472-143191 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213715 WP_002916312.1 NZ_CP081893:807857-808123 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213715 NZ_CP109833:c143696-143469 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References