Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4022145..4022764 Replicon chromosome
Accession NZ_CP081892
Organism Klebsiella pneumoniae strain NY-06

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ657_RS19860 Protein ID WP_002892050.1
Coordinates 4022546..4022764 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ657_RS19855 Protein ID WP_002892066.1
Coordinates 4022145..4022519 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ657_RS19845 (4017297) 4017297..4018490 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ657_RS19850 (4018513) 4018513..4021659 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KZ657_RS19855 (4022145) 4022145..4022519 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ657_RS19860 (4022546) 4022546..4022764 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ657_RS19865 (4022923) 4022923..4023489 + 567 WP_002892030.1 maltose O-acetyltransferase -
KZ657_RS19870 (4023461) 4023461..4023601 - 141 WP_004147370.1 hypothetical protein -
KZ657_RS19875 (4023622) 4023622..4024092 + 471 WP_002892026.1 YlaC family protein -
KZ657_RS19880 (4024067) 4024067..4025518 - 1452 WP_223098305.1 PLP-dependent aminotransferase family protein -
KZ657_RS19885 (4025619) 4025619..4026317 + 699 WP_080899866.1 GNAT family protein -
KZ657_RS19890 (4026314) 4026314..4026454 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ657_RS19895 (4026454) 4026454..4026717 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213710 WP_002892050.1 NZ_CP081892:4022546-4022764 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213710 NZ_CP109824:4645206-4645517 [Serratia marcescens]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAGCAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGGCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTACGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCGTCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213710 WP_002892066.1 NZ_CP081892:4022145-4022519 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213710 NZ_CP109824:4645514-4645936 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTACCCTTATTGCAGGGCAGCCACGCTCAGCAAGA
CTACCGAGAAGCGCTCGAATTGGTGGAATATCTGCTGGAAAACGATGAACACCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACTGCATTCAACCAGCGTATCGCCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTATTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCTAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References