Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2629048..2630636 Replicon chromosome
Accession NZ_CP081892
Organism Klebsiella pneumoniae strain NY-06

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag KZ657_RS13045 Protein ID WP_002904792.1
Coordinates 2629048..2630370 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag KZ657_RS13050 Protein ID WP_002904790.1
Coordinates 2630370..2630636 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ657_RS13025 (2624219) 2624219..2626281 + 2063 Protein_2550 fimbrial biogenesis outer membrane usher protein -
KZ657_RS13030 (2626324) 2626324..2626614 + 291 WP_261945528.1 FimD/PapC C-terminal domain-containing protein -
KZ657_RS13035 (2626602) 2626602..2627606 + 1005 WP_065800701.1 fimbrial protein -
KZ657_RS13040 (2627739) 2627739..2629031 + 1293 WP_223099094.1 glycoside hydrolase family 10 protein -
KZ657_RS13045 (2629048) 2629048..2630370 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
KZ657_RS13050 (2630370) 2630370..2630636 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KZ657_RS13055 (2631023) 2631023..2631349 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KZ657_RS13060 (2631346) 2631346..2631846 - 501 WP_069376095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KZ657_RS13065 (2631824) 2631824..2633203 - 1380 WP_023341546.1 nucleobase:cation symporter-2 family protein -
KZ657_RS13070 (2633549) 2633549..2634703 + 1155 WP_048265552.1 FAD-dependent urate hydroxylase HpxO -
KZ657_RS13075 (2634684) 2634684..2635607 - 924 WP_223099097.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T213708 WP_002904792.1 NZ_CP081892:c2630370-2629048 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T213708 NZ_CP109824:c4305890-4305468 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTTTTTTCCCTGTTGACTCATGGCGTTCTGATCTT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTATGGCCCGCTTTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGTAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGTTTCAGCTGGCACGGCCGA
GAATGGCGGCTGGCGAAAAAGCCCTGGATGCCGGGCTACGGCCTGCTGCTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT213708 WP_002904790.1 NZ_CP081892:c2630636-2630370 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT213708 NZ_CP109824:c4306137-4305871 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References