Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834020..834677 Replicon chromosome
Accession NZ_CP081892
Organism Klebsiella pneumoniae strain NY-06

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KZ657_RS04195 Protein ID WP_002916310.1
Coordinates 834267..834677 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ657_RS04190 Protein ID WP_002916312.1
Coordinates 834020..834286 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ657_RS04165 (829176) 829176..830609 - 1434 WP_023328360.1 6-phospho-beta-glucosidase BglA -
KZ657_RS04170 (830728) 830728..831456 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KZ657_RS04175 (831506) 831506..831817 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KZ657_RS04180 (831981) 831981..832640 + 660 WP_002916317.1 hemolysin III family protein -
KZ657_RS04185 (832791) 832791..833774 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
KZ657_RS04190 (834020) 834020..834286 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ657_RS04195 (834267) 834267..834677 + 411 WP_002916310.1 protein YgfX Toxin
KZ657_RS04200 (834684) 834684..835205 - 522 WP_004144730.1 flavodoxin FldB -
KZ657_RS04205 (835306) 835306..836202 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZ657_RS04210 (836225) 836225..836938 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ657_RS04215 (836944) 836944..838677 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213698 WP_002916310.1 NZ_CP081892:834267-834677 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213698 NZ_CP109815:c8792-8139 [Campylobacter coli]
ATGAAAGAAAGCAATGAAGAACTCTTTAAAAGATTAATTACAGATAATAAACTCGGTATAAAAGATGAAAAATTATTTGA
TAAAGAATCAAGAAAATATACTCTAACAAGAACTAAAGAAATAATTAAAACGCCTATCAAAGGCAATTTTGATTATCAGC
ATTTGAAAAATATACATAAATATATTTTTCAAGATGTATTTCACTGGGCTGGAAAAGATAGAATGGAAGTAGGCTTGCAT
GGAAATTTTGGAAAATATGCACCAAATGGAACAATTACTAATTTTGTTCCCGGAAAAGATTTAAATGCAACCGCTCAACA
AATTTTTACTTGGCTTAAAGAAGACAATTACTTAAAAAATTCAAAAGATCTTAACGATTTCGCAAAGAACTTAGCCGAAT
TTGCTAGAAATCTAAATGCTTTGCACCCCTTTAGAGAAGGTAACGGCAGAACTCAAAGAATATTTTTAAATGAGTTGGCT
AAAAATGCAGGTTATAAACTTGATTTAAATTTAATACCAAAAGATAAAACGATAATGGCATCTGTAGAAGCTTCACAATT
GAAATTAGGAAAACTTGAAGCCATAATTAAAACCAATCTAAAAAGCTTTAGACAAAACTTAGATTTAGAGCAAAATAAAG
GAATATCATTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213698 WP_002916312.1 NZ_CP081892:834020-834286 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213698 NZ_CP109815:c9030-8776 [Campylobacter coli]
ATGCAAAAACAATATCCCGAAGTGCATAGCTTAGAAGAAAGCCTTGCAATACTTAAAAAATATAAAGATGATGTAAGCAA
AAAAGACTATGAAGAAATTAAATCTACCATTTGCGGACACGCTATCGAAGATATATTTGCAAATGAAGAAGATATTATTA
TGCTAGTAAAAATGAGTGCATATAATCTAAGTAGTGATGAGATAATAGCAGAATACAAAGAAAAGGGATTTGTAGAATAT
GAAAGAAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References