Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4759192..4759708 Replicon chromosome
Accession NZ_CP081891
Organism Klebsiella pneumoniae strain CT-04

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KZ663_RS23100 Protein ID WP_004178374.1
Coordinates 4759192..4759476 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KZ663_RS23105 Protein ID WP_002886901.1
Coordinates 4759466..4759708 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ663_RS23075 (KZ663_23015) 4754588..4754851 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KZ663_RS23080 (KZ663_23020) 4754981..4755154 + 174 WP_032408826.1 hypothetical protein -
KZ663_RS23085 (KZ663_23025) 4755157..4755900 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KZ663_RS23090 (KZ663_23030) 4756257..4758395 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
KZ663_RS23095 (KZ663_23035) 4758724..4759188 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZ663_RS23100 (KZ663_23040) 4759192..4759476 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ663_RS23105 (KZ663_23045) 4759466..4759708 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZ663_RS23110 (KZ663_23050) 4759786..4761696 - 1911 WP_009486549.1 PRD domain-containing protein -
KZ663_RS23115 (KZ663_23055) 4761719..4762873 - 1155 WP_004178372.1 lactonase family protein -
KZ663_RS23120 (KZ663_23060) 4762940..4763680 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T213693 WP_004178374.1 NZ_CP081891:c4759476-4759192 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213693 NZ_CP109798:534761-535102 [Enterococcus faecium]
GTGTCAGGAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTTATTTTGATCCCTCATTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213693 WP_002886901.1 NZ_CP081891:c4759708-4759466 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213693 NZ_CP109798:534531-534761 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGACGATGGTACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References