Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4033801..4034420 Replicon chromosome
Accession NZ_CP081891
Organism Klebsiella pneumoniae strain CT-04

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ663_RS19645 Protein ID WP_002892050.1
Coordinates 4034202..4034420 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ663_RS19640 Protein ID WP_002892066.1
Coordinates 4033801..4034175 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ663_RS19630 (KZ663_19565) 4028953..4030146 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ663_RS19635 (KZ663_19570) 4030169..4033315 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KZ663_RS19640 (KZ663_19575) 4033801..4034175 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ663_RS19645 (KZ663_19580) 4034202..4034420 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ663_RS19650 (KZ663_19585) 4034579..4035145 + 567 WP_002892030.1 maltose O-acetyltransferase -
KZ663_RS19655 (KZ663_19590) 4035117..4035257 - 141 WP_004147370.1 hypothetical protein -
KZ663_RS19660 (KZ663_19595) 4035278..4035748 + 471 WP_002892026.1 YlaC family protein -
KZ663_RS19665 (KZ663_19600) 4035723..4037174 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KZ663_RS19670 (KZ663_19605) 4037275..4037973 + 699 WP_002892021.1 GNAT family protein -
KZ663_RS19675 (KZ663_19610) 4037970..4038110 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ663_RS19680 (KZ663_19615) 4038110..4038373 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213690 WP_002892050.1 NZ_CP081891:4034202-4034420 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213690 NZ_CP109795:2015057-2015233 [Bacillus velezensis]
GTGTTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213690 WP_002892066.1 NZ_CP081891:4033801-4034175 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213690 NZ_CP109795:c2015116-2015021 [Bacillus velezensis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAACACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References