Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789445..790102 Replicon chromosome
Accession NZ_CP081891
Organism Klebsiella pneumoniae strain CT-04

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KZ663_RS03930 Protein ID WP_002916310.1
Coordinates 789692..790102 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ663_RS03925 Protein ID WP_002916312.1
Coordinates 789445..789711 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ663_RS03900 (KZ663_03895) 784602..786035 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KZ663_RS03905 (KZ663_03900) 786153..786881 - 729 WP_087637090.1 MurR/RpiR family transcriptional regulator -
KZ663_RS03910 (KZ663_03905) 786931..787242 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KZ663_RS03915 (KZ663_03910) 787406..788065 + 660 WP_002916317.1 hemolysin III family protein -
KZ663_RS03920 (KZ663_03915) 788216..789199 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KZ663_RS03925 (KZ663_03920) 789445..789711 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ663_RS03930 (KZ663_03925) 789692..790102 + 411 WP_002916310.1 protein YgfX Toxin
KZ663_RS03935 (KZ663_03930) 790109..790630 - 522 WP_004144730.1 flavodoxin FldB -
KZ663_RS03940 (KZ663_03935) 790731..791627 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZ663_RS03945 (KZ663_03940) 791650..792363 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ663_RS03950 (KZ663_03945) 792369..794102 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213679 WP_002916310.1 NZ_CP081891:789692-790102 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213679 NZ_CP109775:2160577-2160867 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213679 WP_002916312.1 NZ_CP081891:789445-789711 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213679 NZ_CP109775:2160383-2160577 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References