Detailed information of TA system TA213672

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4566249..4566929
• Replicon: chromosome
• Accession: NZ_CP081890
• Organism: Klebsiella pneumoniae strain IA-021

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KZ660_RS22420
• Protein ID: WP_075648423.1
• Coordinates: 4566249..4566569 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KZ660_RS22425
• Protein ID: WP_075648421.1
• Coordinates: 4566606..4566929 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ660_RS22390 (4561543)	4561543..4561809	+	267	WP_004178415.1	hypothetical protein	-
KZ660_RS22395 (4561809)	4561809..4562481	+	673	Protein_4394	DUF4400 domain-containing protein	-
KZ660_RS22400 (4562492)	4562492..4563376	+	885	WP_004192285.1	RES domain-containing protein	-
KZ660_RS22405 (4563575)	4563575..4563763	-	189	Protein_4396	transposase	-
KZ660_RS22410 (4563780)	4563780..4564891	-	1112	Protein_4397	IS3 family transposase	-
KZ660_RS22415 (4565302)	4565302..4566135	-	834	WP_043018277.1	DUF4942 domain-containing protein	-
KZ660_RS22420 (4566249)	4566249..4566569	-	321	WP_075648423.1	TA system toxin CbtA family protein	Toxin
KZ660_RS22425 (4566606)	4566606..4566929	-	324	WP_075648421.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KZ660_RS22430 (4566942)	4566942..4567394	-	453	WP_223106444.1	DNA repair protein RadC	-
KZ660_RS22435 (4567482)	4567482..4568689	+	1208	WP_085955172.1	IS3 family transposase	-
KZ660_RS22440 (4568835)	4568835..4569656	-	822	WP_081423567.1	DUF932 domain-containing protein	-
KZ660_RS22445 (4569766)	4569766..4570176	-	411	WP_227658064.1	IrmA family protein	-
KZ660_RS22450 (4570359)	4570359..4571006	-	648	WP_043018271.1	hypothetical protein	-
KZ660_RS22455 (4571012)	4571012..4571713	-	702	WP_043018270.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4555654..4589664	34010
	-	inside	IScluster/Tn	-	-	4563975..4568689	4714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12037.69 Da
• Isoelectric Point: 6.0641

>T213672 WP_075648423.1 NZ_CP081890:c4566569-4566249 [Klebsiella pneumoniae]
MHISSVPATVPVSSRLSPVQVWQQLLTYLLDRHYGLTLNDTPFHNDAAIEEHIEAGITLADAVNFLVERYELVRTDRKGF
SWQEQTPFLTVTDILRAKRATGLMNT

Nucleotide

• Length: 321 bp

>T213672 NZ_CP109775:745741-746076 [Shigella sonnei]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11991.67 Da
• Isoelectric Point: 6.0522

>AT213672 WP_075648421.1 NZ_CP081890:c4566929-4566606 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFGARLVQEGNRLYYLADRAGLTGSFSPMHLQKIDLAFPVFVEQLEDMLRAGELNPHQQHQVT
IQLASLTCIADTRGSCGYVYISIYPAQ

Nucleotide

• Length: 324 bp

>AT213672 NZ_CP109775:745493-745741 [Shigella sonnei]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA