Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807594..808251 Replicon chromosome
Accession NZ_CP081890
Organism Klebsiella pneumoniae strain IA-021

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KZ660_RS04005 Protein ID WP_002916310.1
Coordinates 807841..808251 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ660_RS04000 Protein ID WP_002916312.1
Coordinates 807594..807860 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ660_RS03975 (802750) 802750..804183 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KZ660_RS03980 (804302) 804302..805030 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KZ660_RS03985 (805080) 805080..805391 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KZ660_RS03990 (805555) 805555..806214 + 660 WP_002916317.1 hemolysin III family protein -
KZ660_RS03995 (806365) 806365..807348 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KZ660_RS04000 (807594) 807594..807860 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ660_RS04005 (807841) 807841..808251 + 411 WP_002916310.1 protein YgfX Toxin
KZ660_RS04010 (808258) 808258..808779 - 522 WP_002916308.1 flavodoxin FldB -
KZ660_RS04015 (808880) 808880..809776 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZ660_RS04020 (809799) 809799..810512 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ660_RS04025 (810518) 810518..812251 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213660 WP_002916310.1 NZ_CP081890:807841-808251 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213660 NZ_CP109772:c1856784-1856368 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213660 WP_002916312.1 NZ_CP081890:807594-807860 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213660 NZ_CP109772:c1857011-1856781 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References