Detailed information of TA system TA213651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2588631..2590219
• Replicon: chromosome
• Accession: NZ_CP081889
• Organism: Klebsiella pneumoniae strain IA-044

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KZ664_RS12750
• Protein ID: WP_048337706.1
• Coordinates: 2588631..2589953 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: KZ664_RS12755
• Protein ID: WP_002904790.1
• Coordinates: 2589953..2590219 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ664_RS12735 (KZ664_12725)	2583687..2586188	+	2502	WP_048337707.1	fimbria/pilus outer membrane usher protein	-
KZ664_RS12740 (KZ664_12730)	2586176..2587180	+	1005	WP_048265557.1	fimbrial protein	-
KZ664_RS12745 (KZ664_12735)	2587322..2588614	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KZ664_RS12750 (KZ664_12740)	2588631..2589953	-	1323	WP_048337706.1	type II toxin-antitoxin system HipA family toxin	Toxin
KZ664_RS12755 (KZ664_12745)	2589953..2590219	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KZ664_RS12760 (KZ664_12750)	2590485..2590811	-	327	WP_048265555.1	hydroxyisourate hydrolase	-
KZ664_RS12765 (KZ664_12755)	2590808..2591308	-	501	WP_048337705.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KZ664_RS12770 (KZ664_12760)	2591286..2592665	-	1380	WP_048337704.1	nucleobase:cation symporter-2 family protein	-
KZ664_RS12775 (KZ664_12765)	2593011..2594165	+	1155	WP_048337703.1	FAD-dependent urate hydroxylase HpxO	-
KZ664_RS12780 (KZ664_12770)	2594146..2595069	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49127.41 Da
• Isoelectric Point: 7.5357

>T213651 WP_048337706.1 NZ_CP081889:c2589953-2588631 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDVISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T213651 NZ_CP109753:4568381-4568484 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT213651 WP_002904790.1 NZ_CP081889:c2590219-2589953 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT213651 NZ_CP109753:c4568489-4568346 [Enterobacter roggenkampii]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8