Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 790396..791053 Replicon chromosome
Accession NZ_CP081889
Organism Klebsiella pneumoniae strain IA-044

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KZ664_RS03935 Protein ID WP_002916310.1
Coordinates 790643..791053 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ664_RS03930 Protein ID WP_002916312.1
Coordinates 790396..790662 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ664_RS03905 (KZ664_03900) 785552..786985 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KZ664_RS03910 (KZ664_03905) 787104..787832 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KZ664_RS03915 (KZ664_03910) 787882..788193 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KZ664_RS03920 (KZ664_03915) 788357..789016 + 660 WP_002916317.1 hemolysin III family protein -
KZ664_RS03925 (KZ664_03920) 789167..790150 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KZ664_RS03930 (KZ664_03925) 790396..790662 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ664_RS03935 (KZ664_03930) 790643..791053 + 411 WP_002916310.1 protein YgfX Toxin
KZ664_RS03940 (KZ664_03935) 791060..791581 - 522 WP_004144730.1 flavodoxin FldB -
KZ664_RS03945 (KZ664_03940) 791682..792578 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZ664_RS03950 (KZ664_03945) 792601..793314 + 714 WP_048290928.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ664_RS03955 (KZ664_03950) 793320..795053 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213642 WP_002916310.1 NZ_CP081889:790643-791053 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213642 NZ_CP109746:c59207-58857 [Citrobacter portucalensis]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213642 WP_002916312.1 NZ_CP081889:790396-790662 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213642 NZ_CP109746:c58852-58550 [Citrobacter portucalensis]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References