21364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2086904..2087424 Replicon chromosome
Accession NC_007622
Organism Staphylococcus aureus RF122

Toxin (Protein)


Gene name mazF Uniprot ID Q2YUI5
Locus tag SAB_RS10590 Protein ID WP_000621174.1
Coordinates 2086904..2087257 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAB_RS10595 Protein ID WP_000948331.1
Coordinates 2087254..2087424 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAB_RS10565 2083874..2084644 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
SAB_RS10570 2084619..2085098 - 480 WP_001190825.1 anti-sigma B factor RsbW -
SAB_RS10575 2085100..2085426 - 327 WP_001052490.1 anti-sigma factor antagonist -
SAB_RS10580 2085545..2086546 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
SAB_RS10590 2086904..2087257 - 354 WP_000621174.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SAB_RS10595 2087254..2087424 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SAB_RS10600 2087509..2088657 - 1149 WP_001281138.1 alanine racemase -
SAB_RS10605 2088723..2089082 - 360 WP_000581197.1 holo-ACP synthase -
SAB_RS10610 2089086..2089577 - 492 WP_001286981.1 PH domain-containing protein -
SAB_RS10615 2089570..2091147 - 1578 WP_001294634.1 PH domain-containing protein -
SAB_RS10620 2091140..2091619 - 480 WP_001287074.1 hypothetical protein -
SAB_RS10625 2091823..2092383 - 561 WP_001092404.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13071.28 Da        Isoelectric Point: 10.0474

>T21364 WP_000621174.1 NC_007622:c2087257-2086904 [Staphylococcus aureus RF122]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAH

Download         Length: 354 bp

>T21364 NC_007622:c2087257-2086904 [Staphylococcus aureus RF122]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT21364 WP_000948331.1 NC_007622:c2087424-2087254 [Staphylococcus aureus RF122]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT21364 NC_007622:c2087424-2087254 [Staphylococcus aureus RF122]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q2YUI5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References