Detailed information of TA system TA021363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1913710..1914486
• Replicon: chromosome
• Accession: NC_007622
• Organism: Staphylococcus aureus RF122

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: SAB_RS09555
• Protein ID: WP_000031105.1
• Coordinates: 1913710..1913862 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0D1IYN8
• Locus tag: SAB_RS09560
• Protein ID: WP_001251219.1
• Coordinates: 1913887..1914486 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAB_RS09535	1909976..1910797	+	822	WP_000669372.1	RluA family pseudouridine synthase	-
SAB_RS09540	1911248..1912633	-	1386	WP_000116236.1	class II fumarate hydratase	-
SAB_RS09545	1912829..1913224	-	396	WP_000901023.1	hypothetical protein	-
SAB_RS09555	1913710..1913862	-	153	WP_000031105.1	hypothetical protein	Toxin
SAB_RS09560	1913887..1914486	-	600	WP_001251219.1	glucosamine-6-phosphate isomerase	Antitoxin
SAB_RS09565	1914645..1915115	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SAB_RS09570	1915120..1916247	-	1128	WP_000379976.1	tRNA epoxyqueuosine(34) reductase QueG	-
SAB_RS09575	1916398..1917120	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
SAB_RS09580	1917113..1918570	-	1458	WP_000649895.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5922.25 Da
• Isoelectric Point: 3.8849

>T21363 WP_000031105.1 NC_007622:c1913862-1913710 [Staphylococcus aureus RF122]
MSKDKDPKLNYHEEENSMVTDFEDLKDLGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T21363 NC_007622:c1913862-1913710 [Staphylococcus aureus RF122]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
TTTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22357.50 Da
• Isoelectric Point: 5.1445

>AT21363 WP_001251219.1 NC_007622:c1914486-1913887 [Staphylococcus aureus RF122]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT21363 NC_007622:c1914486-1913887 [Staphylococcus aureus RF122]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCGGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1IYN8