Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4277187..4277782 Replicon chromosome
Accession NZ_CP081881
Organism Escherichia coli strain WW2

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag K5O11_RS20460 Protein ID WP_000239581.1
Coordinates 4277187..4277537 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag K5O11_RS20465 Protein ID WP_001223213.1
Coordinates 4277531..4277782 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O11_RS20440 (4272641) 4272641..4273663 - 1023 WP_001361374.1 ABC transporter permease -
K5O11_RS20445 (4273677) 4273677..4275179 - 1503 WP_001095661.1 ATP-binding cassette domain-containing protein -
K5O11_RS20450 (4275312) 4275312..4276268 - 957 WP_108997067.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K5O11_RS20455 (4276578) 4276578..4277108 + 531 WP_000055072.1 inorganic diphosphatase -
K5O11_RS20460 (4277187) 4277187..4277537 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
K5O11_RS20465 (4277531) 4277531..4277782 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
K5O11_RS20470 (4277994) 4277994..4278335 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
K5O11_RS20475 (4278338) 4278338..4282117 - 3780 WP_108997070.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T213626 WP_000239581.1 NZ_CP081881:c4277537-4277187 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T213626 NZ_CP109739:c4846552-4846456 [Serratia nevei]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT213626 WP_001223213.1 NZ_CP081881:c4277782-4277531 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT213626 NZ_CP109739:4846456-4846596 [Serratia nevei]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References