Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4265843..4266365 Replicon chromosome
Accession NZ_CP081881
Organism Escherichia coli strain WW2

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag K5O11_RS20400 Protein ID WP_001105432.1
Coordinates 4265843..4266133 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag K5O11_RS20405 Protein ID WP_000212715.1
Coordinates 4266123..4266365 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O11_RS20385 (4261006) 4261006..4262661 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
K5O11_RS20390 (4263055) 4263055..4265193 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
K5O11_RS20395 (4265378) 4265378..4265842 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5O11_RS20400 (4265843) 4265843..4266133 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5O11_RS20405 (4266123) 4266123..4266365 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5O11_RS20410 (4266557) 4266557..4266943 - 387 WP_001232253.1 cytochrome b562 -
K5O11_RS20415 (4266999) 4266999..4268351 - 1353 WP_001162172.1 metalloprotease PmbA -
K5O11_RS20420 (4268445) 4268445..4268996 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
K5O11_RS20425 (4269079) 4269079..4270452 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T213625 WP_001105432.1 NZ_CP081881:c4266133-4265843 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T213625 NZ_CP109739:3674033-3674431 [Serratia nevei]
ATGTTCAGCCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCGATTACCTATGGCGAATTGGTTCACGGGGTGGAGAACAGCGCTCGCCCAG
CGGTGAACGCCAGAGTCGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGTGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAGCGCGTTGAGGGTTTGCGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT213625 WP_000212715.1 NZ_CP081881:c4266365-4266123 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT213625 NZ_CP109739:3673800-3674033 [Serratia nevei]
ATGGCGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCCTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGCTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGACAGCACCAACGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References