Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 10115..10605 Replicon plasmid p1-UTDF19-27C
Accession NZ_CP081879
Organism Exiguobacterium acetylicum strain UTDF19-27C

Toxin (Protein)


Gene name relE Uniprot ID A0A0V8GC58
Locus tag K6T22_RS16545 Protein ID WP_047395636.1
Coordinates 10336..10605 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A031ILR5
Locus tag K6T22_RS16540 Protein ID WP_026829710.1
Coordinates 10115..10339 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6T22_RS16525 (K6T22_16525) 5447..7576 + 2130 WP_017474135.1 heavy metal translocating P-type ATPase -
K6T22_RS16530 (K6T22_16530) 7777..8760 - 984 WP_214725543.1 HAD-IC family P-type ATPase -
K6T22_RS16535 (K6T22_16535) 8775..9917 + 1143 WP_114597504.1 hypothetical protein -
K6T22_RS16540 (K6T22_16540) 10115..10339 + 225 WP_026829710.1 DUF6290 family protein Antitoxin
K6T22_RS16545 (K6T22_16545) 10336..10605 + 270 WP_047395636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6T22_RS16550 (K6T22_16550) 11009..11737 - 729 WP_238240377.1 GntR family transcriptional regulator -
K6T22_RS16555 (K6T22_16555) 11820..13241 - 1422 WP_238240379.1 glycoside hydrolase family 1 protein -
K6T22_RS16560 (K6T22_16560) 13289..14626 - 1338 WP_029343446.1 PTS cellobiose transporter subunit IIC -
K6T22_RS16565 (K6T22_16565) 14642..14971 - 330 WP_029343447.1 PTS lactose/cellobiose transporter subunit IIA -
K6T22_RS16570 (K6T22_16570) 14977..15273 - 297 WP_026828592.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..184468 184468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10457.13 Da        Isoelectric Point: 10.5148

>T213599 WP_047395636.1 NZ_CP081879:10336-10605 [Exiguobacterium acetylicum]
MTAFTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Download         Length: 270 bp

>T213599 NZ_CP109698:c301210-300923 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8599.76 Da        Isoelectric Point: 4.5010

>AT213599 WP_026829710.1 NZ_CP081879:10115-10339 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFDDMMKELDLE

Download         Length: 225 bp

>AT213599 NZ_CP109698:c301449-301210 [Enterobacter asburiae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8GC58

Antitoxin

Source ID Structure
AlphaFold DB A0A031ILR5

References