Detailed information of TA system TA213598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1389358..1389848
• Replicon: chromosome
• Accession: NZ_CP081878
• Organism: Exiguobacterium acetylicum strain UTDF19-27C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6T22_RS07115
• Protein ID: WP_035408288.1
• Coordinates: 1389358..1389627 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A031ILR5
• Locus tag: K6T22_RS07120
• Protein ID: WP_026829710.1
• Coordinates: 1389624..1389848 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6T22_RS07100 (K6T22_07095)	1384768..1386897	+	2130	WP_238239676.1	AAA family ATPase	-
K6T22_RS07105 (K6T22_07100)	1386884..1388161	+	1278	WP_238239677.1	McrC family protein	-
K6T22_RS07110 (K6T22_07105)	1388545..1389054	+	510	WP_238239678.1	hypothetical protein	-
K6T22_RS07115 (K6T22_07110)	1389358..1389627	-	270	WP_035408288.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6T22_RS07120 (K6T22_07115)	1389624..1389848	-	225	WP_026829710.1	DUF6290 family protein	Antitoxin
K6T22_RS07125 (K6T22_07120)	1389980..1390480	-	501	WP_238239679.1	tautomerase family protein	-
K6T22_RS07130 (K6T22_07125)	1390480..1390956	-	477	WP_238239680.1	heme-degrading domain-containing protein	-
K6T22_RS07135 (K6T22_07130)	1390998..1391831	-	834	WP_283205704.1	aldo/keto reductase	-
K6T22_RS07140 (K6T22_07135)	1392063..1392392	-	330	WP_058705278.1	winged helix-turn-helix transcriptional regulator	-
K6T22_RS07145 (K6T22_07140)	1392738..1392986	+	249	WP_238239683.1	hypothetical protein	-
K6T22_RS07150 (K6T22_07145)	1393033..1393677	+	645	WP_238239684.1	hypothetical protein	-
K6T22_RS07155 (K6T22_07150)	1393649..1394332	+	684	WP_238239686.1	hypothetical protein	-
K6T22_RS07160 (K6T22_07155)	1394439..1394747	+	309	WP_238239687.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10486.13 Da
• Isoelectric Point: 10.3966

>T213598 WP_035408288.1 NZ_CP081878:c1389627-1389358 [Exiguobacterium acetylicum]
MTAYNVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Nucleotide

• Length: 270 bp

>T213598 NZ_CP109697:67422-67838 [Enterobacter asburiae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8599.76 Da
• Isoelectric Point: 4.5010

>AT213598 WP_026829710.1 NZ_CP081878:c1389848-1389624 [Exiguobacterium acetylicum]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFDDMMKELDLE

Nucleotide

• Length: 225 bp

>AT213598 NZ_CP109697:67195-67425 [Enterobacter asburiae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A031ILR5