Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5016827..5017460 Replicon chromosome
Accession NZ_CP081869
Organism Chenggangzhangella methanolivorans strain CHL1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K6K41_RS26465 Protein ID WP_261403012.1
Coordinates 5016827..5017018 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K6K41_RS26470 Protein ID WP_261403013.1
Coordinates 5017035..5017460 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K41_RS26445 (K6K41_25125) 5012470..5012976 + 507 WP_261403008.1 hypothetical protein -
K6K41_RS26450 (K6K41_25130) 5013123..5014349 + 1227 WP_261403009.1 MFS transporter -
K6K41_RS26455 (K6K41_25135) 5014585..5015568 + 984 WP_261403010.1 MDR family oxidoreductase -
K6K41_RS26460 (K6K41_25140) 5015713..5016765 + 1053 WP_261403011.1 N-acetyl-gamma-glutamyl-phosphate reductase -
K6K41_RS26465 (K6K41_25145) 5016827..5017018 + 192 WP_261403012.1 type II toxin-antitoxin system HicA family toxin Toxin
K6K41_RS26470 (K6K41_25150) 5017035..5017460 + 426 WP_261403013.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6K41_RS26475 (K6K41_25155) 5017483..5019221 - 1739 Protein_5237 class I poly(R)-hydroxyalkanoic acid synthase -
K6K41_RS26480 (K6K41_25160) 5019938..5020174 + 237 WP_261403014.1 hypothetical protein -
K6K41_RS26485 (K6K41_25165) 5020193..5021413 - 1221 WP_261403015.1 calcium-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(10-132)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7200.29 Da        Isoelectric Point: 11.5249

>T213594 WP_261403012.1 NZ_CP081869:5016827-5017018 [Chenggangzhangella methanolivorans]
VERNSRKLIALLKADGWTPVSQDGSHQTFKHTSNPLLITVPHPRKDLPVGLVRRIYRDAGWRT

Download         Length: 192 bp

>T213594 NZ_CP109694:4833850-4834137 [Enterobacter asburiae]
ATGCCAACGGAGTTTGAATGGGATACCAACAAAGCGAAAAGCAATCTCATTAAGCATGGGATCCGCTTTGAAGAAGCTGT
TCTGGTGTTTGACGATCCTTACCATTTATCTTTGCAGGATCGTCATGAAAATGGAGAGTTCCGTTGGCAGACCATTGGCC
TTGTACATGGTCTAATTGTCATTATGGTCGCACACACGGTACGTTTTGAAAGTGGTGACGAAGTCATTCGAATCATTAGC
GCACGAAAGGCGGACCGTAAAGAGAGGAGCCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 14832.71 Da        Isoelectric Point: 4.5164

>AT213594 WP_261403013.1 NZ_CP081869:5017035-5017460 [Chenggangzhangella methanolivorans]
MNAKRYFVGVIEKDEDSAFGVWFPDAPGAYGAADEFEDVISAAGRALRHHVEALQTAGMPTPEPRAYDEVINSADVRAAI
AAGAAAIVVPLLADGGRTVRVNVSIERDLVEQIDAAAEARGLTRSAFLAQAARDKILAGVV

Download         Length: 426 bp

>AT213594 NZ_CP109694:4834124-4834426 [Enterobacter asburiae]
ATGAGCATGGTTAAACATAAACGCGGTAGTGCGCCTGAGATGAGTGCTCGCCGTGAGGCTGAGCTCAAAGCACTAGCCGA
AAAATCGGAAGCAGAGATTGATTACAGCGATATCCCTGCCATGGAAGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTCAAAACTCAGGCGTCTGTACGTATCGACGCTGACGTGATGGAGTGGCTTAAACGGCCTGGAAAAGGT
TACCAGACGAGGCTCAATGCCATTTTGCGTGAAGCTATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References