Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 16325..16968 | Replicon | plasmid pK5880C-NDM |
| Accession | NZ_CP081866 | ||
| Organism | Klebsiella pneumoniae strain K5880C | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q84A06 |
| Locus tag | K6J95_RS26265 | Protein ID | WP_000754566.1 |
| Coordinates | 16552..16968 (+) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | K6J95_RS26260 | Protein ID | WP_001261276.1 |
| Coordinates | 16325..16555 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J95_RS26225 (K6J95_26110) | 11511..11984 | + | 474 | WP_004152341.1 | YkgJ family cysteine cluster protein | - |
| K6J95_RS26230 (K6J95_26115) | 12076..12306 | + | 231 | WP_011977773.1 | hypothetical protein | - |
| K6J95_RS26235 (K6J95_26120) | 13198..13980 | - | 783 | WP_004152340.1 | site-specific integrase | - |
| K6J95_RS26240 (K6J95_26125) | 13980..14312 | - | 333 | WP_004152339.1 | hypothetical protein | - |
| K6J95_RS26245 (K6J95_26130) | 14319..14717 | - | 399 | WP_004171440.1 | hypothetical protein | - |
| K6J95_RS26250 (K6J95_26135) | 14743..15072 | - | 330 | WP_004152337.1 | hypothetical protein | - |
| K6J95_RS26255 (K6J95_26140) | 15100..15408 | - | 309 | WP_004152336.1 | hypothetical protein | - |
| K6J95_RS26260 (K6J95_26145) | 16325..16555 | + | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| K6J95_RS26265 (K6J95_26150) | 16552..16968 | + | 417 | WP_000754566.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K6J95_RS26270 (K6J95_26155) | 17172..18028 | + | 857 | Protein_17 | IS3-like element ISEc15 family transposase | - |
| K6J95_RS26275 (K6J95_26160) | 18310..19386 | + | 1077 | WP_000227969.1 | IS110 family transposase | - |
| K6J95_RS26280 (K6J95_26165) | 19394..19507 | - | 114 | Protein_19 | Tn3 family transposase | - |
| K6J95_RS26285 (K6J95_26170) | 20133..20459 | - | 327 | WP_004201125.1 | C2H2-type zinc finger protein | - |
| K6J95_RS26290 (K6J95_26175) | 20641..20922 | + | 282 | WP_001568067.1 | hypothetical protein | - |
| K6J95_RS26295 (K6J95_26180) | 20976..21587 | + | 612 | WP_000176305.1 | DUF2913 family protein | - |
| K6J95_RS26300 (K6J95_26185) | 21584..21694 | - | 111 | Protein_23 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaNDM-1 / aph(3')-VI / qnrS1 / blaCTX-M-15 / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr | - | 1..55288 | 55288 | |
| - | flank | IS/Tn | - | - | 10123..11391 | 1268 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15006.52 Da Isoelectric Point: 9.2957
>T213593 WP_000754566.1 NZ_CP081866:16552-16968 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK
Download Length: 417 bp
>T213593 NZ_CP109694:c4508369-4508067 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTATAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATCCCAATGGCAGGAGTGAATGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTATAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATCCCAATGGCAGGAGTGAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT213593 WP_001261276.1 NZ_CP081866:16325-16555 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT213593 NZ_CP109694:c4508064-4507777 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCTCTGGGCGTCATCGCGCGAGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCCGAAGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCTCTGGGCGTCATCGCGCGAGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCCGAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K1G3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |