Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4964522..4966203 | Replicon | chromosome |
| Accession | NZ_CP081865 | ||
| Organism | Klebsiella pneumoniae strain K5880C | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A6TH06 |
| Locus tag | K6J95_RS24245 | Protein ID | WP_015959269.1 |
| Coordinates | 4964522..4965397 (-) | Length | 292 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | K6J95_RS24250 | Protein ID | WP_004177809.1 |
| Coordinates | 4965445..4966203 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6J95_RS24225 (4959828) | 4959828..4961348 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| K6J95_RS24230 (4961345) | 4961345..4962343 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| K6J95_RS24235 (4962374) | 4962374..4963315 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| K6J95_RS24240 (4963390) | 4963390..4964397 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| K6J95_RS24245 (4964522) | 4964522..4965397 | - | 876 | WP_015959269.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| K6J95_RS24250 (4965445) | 4965445..4966203 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| K6J95_RS24255 (4966289) | 4966289..4967017 | - | 729 | WP_032413197.1 | response regulator transcription factor | - |
| K6J95_RS24260 (4967290) | 4967290..4969437 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| K6J95_RS24265 (4969434) | 4969434..4969577 | - | 144 | WP_162897205.1 | hypothetical protein | - |
| K6J95_RS24270 (4970015) | 4970015..4970701 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 292 a.a. Molecular weight: 32990.17 Da Isoelectric Point: 5.4637
>T213591 WP_015959269.1 NZ_CP081865:c4965397-4964522 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 876 bp
>T213591 NZ_CP109694:4283567-4283965 [Enterobacter asburiae]
ATGCTGCATATGTTGGATACAAACATGGTAAGCCATCTCGTGAGACAACATCCTGGGGTGTTGGAACAATATTCTCGCAC
CCCAACTGAAAAAATGTGTATTTCAAGCGTAACGGAGGCTGAATTGCTTTATGGGATAGCCAAAAAGCAAAACGACACAT
TACAAAAAACCATACTGGAATTTCTTAAAACCATTACGATTTGCGACTGGGACAGTGACGCCGCCGCAACGTACGGCGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCTATCAGTCGGAG
AACAACGATTGTGACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTACCGTAGAGGACTGGACGACAACGTCGTGA
ATGCTGCATATGTTGGATACAAACATGGTAAGCCATCTCGTGAGACAACATCCTGGGGTGTTGGAACAATATTCTCGCAC
CCCAACTGAAAAAATGTGTATTTCAAGCGTAACGGAGGCTGAATTGCTTTATGGGATAGCCAAAAAGCAAAACGACACAT
TACAAAAAACCATACTGGAATTTCTTAAAACCATTACGATTTGCGACTGGGACAGTGACGCCGCCGCAACGTACGGCGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCTATCAGTCGGAG
AACAACGATTGTGACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTACCGTAGAGGACTGGACGACAACGTCGTGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT213591 WP_004177809.1 NZ_CP081865:c4966203-4965445 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT213591 NZ_CP109694:4283303-4283563 [Enterobacter asburiae]
ATGGAACGCACAGCAAAACTCTTTAAAAAGGGGCGGAATCAGGCCGTAATGATACCTGCTGAATTCGCGTTTGATACGGA
GAGCGTCTACATCCGGCGGGATGAGGAGGGGAATGTCGTTTTGACTGCGAGATCGGAGAAAGAGCGGCATCGAGATAACT
TTTTACGTTTATTGAAGCAGACCCATGTTCCTGATTCATTCCTCAGCAAAGAGGAACGTAATCAGAGCTATACAACAAGA
GATCCCTTTGAAGGACTCTAG
ATGGAACGCACAGCAAAACTCTTTAAAAAGGGGCGGAATCAGGCCGTAATGATACCTGCTGAATTCGCGTTTGATACGGA
GAGCGTCTACATCCGGCGGGATGAGGAGGGGAATGTCGTTTTGACTGCGAGATCGGAGAAAGAGCGGCATCGAGATAACT
TTTTACGTTTATTGAAGCAGACCCATGTTCCTGATTCATTCCTCAGCAAAGAGGAACGTAATCAGAGCTATACAACAAGA
GATCCCTTTGAAGGACTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|