Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4804783..4805299 Replicon chromosome
Accession NZ_CP081865
Organism Klebsiella pneumoniae strain K5880C

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag K6J95_RS23430 Protein ID WP_009486548.1
Coordinates 4804783..4805067 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6J95_RS23435 Protein ID WP_002886901.1
Coordinates 4805057..4805299 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J95_RS23405 (4800200) 4800200..4800508 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
K6J95_RS23410 (4800593) 4800593..4800766 + 174 WP_032433782.1 hypothetical protein -
K6J95_RS23415 (4800769) 4800769..4801512 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6J95_RS23420 (4801869) 4801869..4804007 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K6J95_RS23425 (4804315) 4804315..4804779 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6J95_RS23430 (4804783) 4804783..4805067 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J95_RS23435 (4805057) 4805057..4805299 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6J95_RS23440 (4805377) 4805377..4807287 - 1911 WP_009486549.1 PRD domain-containing protein -
K6J95_RS23445 (4807310) 4807310..4808464 - 1155 WP_002886900.1 lactonase family protein -
K6J95_RS23450 (4808531) 4808531..4809271 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T213590 WP_009486548.1 NZ_CP081865:c4805067-4804783 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213590 NZ_CP109694:c4144762-4144391 [Enterobacter asburiae]
ATGGAGCACATGGCAGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCTCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTCTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAATTGTCCGTTGATTTCTCGAAA
CACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAACTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213590 WP_002886901.1 NZ_CP081865:c4805299-4805057 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213590 NZ_CP109694:c4145007-4144765 [Enterobacter asburiae]
ATAAGTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGTCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References