Detailed information of TA system TA021359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 828053..828530
• Replicon: chromosome
• Accession: NC_007622
• Organism: Staphylococcus aureus RF122

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: SAB_RS04065
• Protein ID: WP_000052076.1
• Coordinates: 828053..828241 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: SAB_RS04070
• Protein ID: WP_001059749.1
• Coordinates: 828270..828530 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAB_RS04035	824056..824565	+	510	WP_000824474.1	hypothetical protein	-
SAB_RS04040	824906..825592	+	687	WP_011382230.1	thermonuclease family protein	-
SAB_RS04045	825949..826149	+	201	WP_001059082.1	cold-shock protein	-
SAB_RS04050	826644..826862	-	219	WP_000005883.1	hypothetical protein	-
SAB_RS04055	826924..827208	-	285	WP_001004397.1	hypothetical protein	-
SAB_RS04060	827296..827865	-	570	WP_001106648.1	hypothetical protein	-
SAB_RS04065	828053..828241	-	189	WP_000052076.1	hypothetical protein	Toxin
SAB_RS04070	828270..828530	-	261	WP_001059749.1	hypothetical protein	Antitoxin
SAB_RS04075	828871..829074	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
SAB_RS04080	829071..829307	-	237	WP_000368687.1	hypothetical protein	-
SAB_RS04085	829532..830113	+	582	WP_001140696.1	phosphoglycerate mutase family protein	-
SAB_RS04090	830186..830803	-	618	WP_000255566.1	LysE/ArgO family amino acid transporter	-
SAB_RS04095	830959..831453	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
SAB_RS04100	831851..832273	-	423	WP_000974458.1	organic hydroperoxide resistance protein	-
SAB_RS04105	832421..833137	+	717	WP_000150029.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T21359 WP_000052076.1 NC_007622:c828241-828053 [Staphylococcus aureus RF122]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T21359 NC_007622:c828241-828053 [Staphylococcus aureus RF122]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9914.01 Da
• Isoelectric Point: 4.0624

>AT21359 WP_001059749.1 NC_007622:c828530-828270 [Staphylococcus aureus RF122]
MNNILSNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT21359 NC_007622:c828530-828270 [Staphylococcus aureus RF122]
ATGAATAACATTTTGTCAAATGCTATAAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18