Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1452646..1453289 Replicon chromosome
Accession NZ_CP081865
Organism Klebsiella pneumoniae strain K5880C

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag K6J95_RS07165 Protein ID WP_032433387.1
Coordinates 1452873..1453289 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag K6J95_RS07160 Protein ID WP_001261276.1
Coordinates 1452646..1452876 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J95_RS07145 (1447668) 1447668..1448755 + 1088 Protein_1395 transcriptional regulator -
K6J95_RS07150 (1448758) 1448758..1450998 + 2241 WP_045326788.1 P-loop NTPase fold protein -
K6J95_RS07155 (1451526) 1451526..1452341 - 816 WP_032433388.1 hypothetical protein -
K6J95_RS07160 (1452646) 1452646..1452876 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K6J95_RS07165 (1452873) 1452873..1453289 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
K6J95_RS07170 (1453445) 1453445..1454425 + 981 WP_032433385.1 hypothetical protein -
K6J95_RS07175 (1454620) 1454620..1456191 - 1572 WP_032433383.1 AAA family ATPase -
K6J95_RS07180 (1456510) 1456510..1456758 + 249 WP_032433382.1 hypothetical protein -
K6J95_RS07185 (1456817) 1456817..1457335 + 519 WP_045326794.1 hypothetical protein -
K6J95_RS07190 (1457366) 1457366..1457857 + 492 WP_032433378.1 hypothetical protein -
K6J95_RS07195 (1457917) 1457917..1458120 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1437282..1483299 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T213577 WP_032433387.1 NZ_CP081865:1452873-1453289 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T213577 NZ_CP109692:4165058-4165345 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT213577 WP_001261276.1 NZ_CP081865:1452646-1452876 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT213577 NZ_CP109692:4164819-4165058 [Enterobacter asburiae]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References