Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4310594..4311226 Replicon chromosome
Accession NZ_CP081864
Organism Symbiopectobacterium purcellii strain SyEd1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K6K13_RS20045 Protein ID WP_222158539.1
Coordinates 4311053..4311226 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K6K13_RS20040 Protein ID WP_222158538.1
Coordinates 4310594..4311001 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K13_RS20010 (K6K13_20010) 4306810..4306964 + 155 Protein_3940 IS1 family transposase -
K6K13_RS20015 (K6K13_20015) 4307307..4307912 - 606 WP_222158534.1 recombinase family protein -
K6K13_RS20020 (K6K13_20020) 4308076..4308756 + 681 Protein_3942 DUF4158 domain-containing protein -
K6K13_RS20025 (K6K13_20025) 4308740..4308985 + 246 WP_222158535.1 hypothetical protein -
K6K13_RS20030 (K6K13_20030) 4309140..4309418 + 279 WP_222158536.1 cobalamin biosynthesis protein CbiX -
K6K13_RS23475 4309501..4309632 + 132 WP_286206773.1 hypothetical protein -
K6K13_RS20035 (K6K13_20035) 4309698..4310054 + 357 WP_222158537.1 hypothetical protein -
K6K13_RS20040 (K6K13_20040) 4310594..4311001 - 408 WP_222158538.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6K13_RS20045 (K6K13_20045) 4311053..4311226 - 174 WP_222158539.1 type II toxin-antitoxin system HicA family toxin Toxin
K6K13_RS20050 (K6K13_20050) 4311382..4311639 + 258 WP_222158540.1 hypothetical protein -
K6K13_RS20055 (K6K13_20055) 4311798..4311992 + 195 WP_196908679.1 ribbon-helix-helix domain-containing protein -
K6K13_RS20060 (K6K13_20060) 4312558..4313043 + 486 WP_222158541.1 single-stranded DNA-binding protein -
K6K13_RS20065 (K6K13_20065) 4313044..4313235 + 192 WP_252120360.1 hypothetical protein -
K6K13_RS20070 (K6K13_20070) 4313469..4314032 - 564 WP_222158542.1 hypothetical protein -
K6K13_RS20075 (K6K13_20075) 4314044..4314751 - 708 WP_222158543.1 StbB family protein -
K6K13_RS20080 (K6K13_20080) 4314753..4315157 - 405 WP_222158544.1 hypothetical protein -
K6K13_RS20085 (K6K13_20085) 4315444..4315791 + 348 WP_222158545.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaD / rfaF 4291099..4342351 51252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6539.73 Da        Isoelectric Point: 10.1505

>T213573 WP_222158539.1 NZ_CP081864:c4311226-4311053 [Symbiopectobacterium purcellii]
MSSRELMKLLEINGWVLDRVKGSHHIFVKDGKDYHITVPHPEKDVAKGTLAKILKQM

Download         Length: 174 bp

>T213573 NZ_CP109692:2512183-2512533 [Enterobacter asburiae]
ATGTGGACGGTTCTGTTCGGTAAGGTATTCGAGCAATGGCTGCTTGAACAGGAAGAAGGATTACAGGATAAGGTACTGGC
AGACCTGCTAAATCTGCAAAAATATGGGCCACGTCTTCCACGGCCCTATGCTGATACGGTTAAAGGCTCATGGTATAACC
ATATGAAAGAATTACGTATTCAATATGCTGGACGTCCGATACGTGCTTTCTTCGCATTTGATCCTGTCCGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGAGTAACGACAAAGCCTTTTATGAAAAAATGATTCGCATCGCAGATACCGAATTTTCCTT
CCATCTGACAAGCCTGGAGGCAACCAAGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14797.58 Da        Isoelectric Point: 4.8616

>AT213573 WP_222158538.1 NZ_CP081864:c4311001-4310594 [Symbiopectobacterium purcellii]
MKFPIYLHQADSGSFSGFAPDIQGVFFAGADIDGAIADAYAAIDAHLEFQAEKGRALPQAQNVKAHLNDEDCQGGFWAFV
EIDLSRYDGKAVKLNITLPQNLLSRIDQYVAVNKDYGSRSGFIADLARRELQKTA

Download         Length: 408 bp

>AT213573 NZ_CP109692:2512530-2512829 [Enterobacter asburiae]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGTTCACCGGAAAGCCAACAACGTATTAAAGAGATGGCAGATGAAATGAT
CCTCGAGACGGGTCTGCAACTTTTACGTGAAGAGCTGAGACTTTCGCAAAAAAATGTTGCCGATTTGATGGGGGTGAGTC
AGCCCGCAGTAACGCAGCTAGAGCAACGTGGAAATGAACTCAAAATTGCCACGCTTAAGCGCTACATTGAGGCAATGGGG
GGGAAACTTCATATCGATATTGAACTTCCCACAGGAAAACGCGTTGCATTTCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References