Detailed information of TA system TA213565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2735049..2735569
• Replicon: chromosome
• Accession: NZ_CP081862
• Organism: Cellulomonas sp. C5510

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K5O09_RS12605
• Protein ID: WP_222169865.1
• Coordinates: 2735049..2735312 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K5O09_RS12610
• Protein ID: WP_222169866.1
• Coordinates: 2735309..2735569 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5O09_RS12575 (K5O09_12575)	2730057..2730344	-	288	WP_222169859.1	DUF1905 domain-containing protein	-
K5O09_RS12580 (K5O09_12580)	2730449..2731813	+	1365	WP_222169860.1	FAD-binding oxidoreductase	-
K5O09_RS12585 (K5O09_12585)	2731838..2732803	-	966	WP_222169861.1	DUF5692 family protein	-
K5O09_RS12590 (K5O09_12590)	2732861..2733475	-	615	WP_222169862.1	TetR/AcrR family transcriptional regulator	-
K5O09_RS12595 (K5O09_12595)	2733579..2733977	+	399	WP_222169863.1	VOC family protein	-
K5O09_RS12600 (K5O09_12600)	2733994..2734965	-	972	WP_222169864.1	dicarboxylate transporter/tellurite-resistance protein TehA	-
K5O09_RS12605 (K5O09_12605)	2735049..2735312	-	264	WP_222169865.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5O09_RS12610 (K5O09_12610)	2735309..2735569	-	261	WP_222169866.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K5O09_RS12615 (K5O09_12615)	2735640..2736056	-	417	WP_222169867.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
K5O09_RS12620 (K5O09_12620)	2736142..2736570	+	429	WP_222169868.1	type II toxin-antitoxin system PemK/MazF family toxin	-
K5O09_RS12625 (K5O09_12625)	2736841..2737614	+	774	WP_255595391.1	Ltp family lipoprotein	-
K5O09_RS12630 (K5O09_12630)	2737979..2740021	-	2043	WP_222169869.1	fibronectin type III domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (24-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10010.43 Da
• Isoelectric Point: 9.5559

>T213565 WP_222169865.1 NZ_CP081862:c2735312-2735049 [Cellulomonas sp. C5510]
MSYRVRWTSAARRALADDLPEAVAAAVWEFVVGPLADNPHRVGKQLVRELEGFWSARRGQYRVIYVIDDGEVVVTVVKVD
HRRDVYR

Nucleotide

• Length: 264 bp

>T213565 NZ_CP109691:31524-32009 [Enterobacter asburiae]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCGCGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9268.44 Da
• Isoelectric Point: 4.8448

>AT213565 WP_222169866.1 NZ_CP081862:c2735569-2735309 [Cellulomonas sp. C5510]
MTTTTSLAHVKAHLSAVVGSVHDTHERVVITRNGEPAAVLISPDDLAALEETLEILSDPETMADLRAAREEIAKGATVEL
SERPRR

Nucleotide

• Length: 261 bp

>AT213565 NZ_CP109691:31270-31536 [Enterobacter asburiae]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA