Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4467467..4468227 Replicon chromosome
Accession NZ_CP081858
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag K6B66_RS21825 Protein ID WP_000533907.1
Coordinates 4467467..4467952 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag K6B66_RS21830 Protein ID WP_000965886.1
Coordinates 4467940..4468227 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6B66_RS21795 (4462529) 4462529..4463191 + 663 WP_000747548.1 OmpA family lipoprotein -
K6B66_RS21800 (4463421) 4463421..4464395 + 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
K6B66_RS21805 (4464445) 4464445..4465155 - 711 WP_000190524.1 DUF3053 domain-containing protein -
K6B66_RS21810 (4465594) 4465594..4465884 + 291 WP_000455790.1 HTH-type transcriptional regulator -
K6B66_RS21815 (4466172) 4466172..4466384 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K6B66_RS21820 (4466557) 4466557..4467096 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
K6B66_RS21825 (4467467) 4467467..4467952 - 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
K6B66_RS21830 (4467940) 4467940..4468227 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
K6B66_RS21835 (4468405) 4468405..4468872 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
K6B66_RS23810 (4469014) 4469014..4469445 - 432 Protein_4288 IS3 family transposase -
K6B66_RS21845 (4469707) 4469707..4471776 - 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
K6B66_RS21850 (4471786) 4471786..4472697 - 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
K6B66_RS21855 (4472836) 4472836..4473138 - 303 WP_000605592.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T213563 WP_000533907.1 NZ_CP081858:c4467952-4467467 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T213563 NZ_CP109657:c5473216-5472938 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGATGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCCATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCTGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACAGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT213563 WP_000965886.1 NZ_CP081858:c4468227-4467940 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT213563 NZ_CP109657:c5472926-5472621 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGACGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAACGTCTCCGCCCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGTTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References