Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3766318..3766978 Replicon chromosome
Accession NZ_CP081858
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K6B66_RS18390 Protein ID WP_000244756.1
Coordinates 3766318..3766731 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K6B66_RS18395 Protein ID WP_000351186.1
Coordinates 3766712..3766978 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6B66_RS18370 (3762259) 3762259..3763992 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
K6B66_RS18375 (3763998) 3763998..3764711 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6B66_RS18380 (3764735) 3764735..3765631 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K6B66_RS18385 (3765744) 3765744..3766265 + 522 WP_001055885.1 flavodoxin FldB -
K6B66_RS18390 (3766318) 3766318..3766731 - 414 WP_000244756.1 protein YgfX Toxin
K6B66_RS18395 (3766712) 3766712..3766978 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K6B66_RS18400 (3767228) 3767228..3768208 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
K6B66_RS18405 (3768324) 3768324..3768983 - 660 WP_000250289.1 hemolysin III family protein -
K6B66_RS18410 (3769147) 3769147..3769458 - 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
K6B66_RS18415 (3769616) 3769616..3771049 + 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T213562 WP_000244756.1 NZ_CP081858:c3766731-3766318 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T213562 NZ_CP109657:c4865647-4865360 [Pseudomonas aeruginosa]
GTGCGCGTACTTGAGTGGCGCGAAGCTGCCCGCGCCGACCTGCTGGCGATTGTTGACTACATCTCGGACGACAACCCCGA
TGCCGCGCAGCGGTTGAAGGACGACATCGAGGCCAAGGCCGCGAAGCTGCCGGAGCGCCCGAAGCTCTACCGGCCTGGCC
GCGTGGCCGGCACGCGGGAAATGGTCGTGCGCTCGAACTACGTGGTGGTCTACGTGGAGGACAGCCGCGCGGTGTCCATC
CTGCGCGTGTTGCACGCCGCGCAGCAGTGGCCGCCGGCACGGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT213562 WP_000351186.1 NZ_CP081858:c3766978-3766712 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213562 NZ_CP109657:c4865933-4865634 [Pseudomonas aeruginosa]
ATGGCCGCACAGACTTCGATGCTGCACATCCGTGTGGACGACAAGCTCAAGGCCGATGCCGCCGAGAAGCTCGCCGGGGT
CGGCCTCACCGTTTCGGACGCCGTACGCATCCTGCTGACCCGTGTGGTCAAGGAAGGCGCGCTGCCGGCTGGCCTCACGG
CCGATCCGGAGGCCTACGATGCCTGGTTCCGGGCGAAGGTCCAGGAGGCGCTGGCCGACACACGGCCGCCGGTGCCGCAC
CAGCAGGTCATGGACGAGGCGCAGGCCCTGATCGACAGGAAGCGGCGTGCGCGTACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References