Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-YafN |
| Location | 2251590..2252112 | Replicon | chromosome |
| Accession | NZ_CP081858 | ||
| Organism | Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16 | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A5J1ICX1 |
| Locus tag | K6B66_RS11140 | Protein ID | WP_000221344.1 |
| Coordinates | 2251590..2251874 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | V1H457 |
| Locus tag | K6B66_RS11145 | Protein ID | WP_000885424.1 |
| Coordinates | 2251864..2252112 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6B66_RS11115 (2246594) | 2246594..2247835 | - | 1242 | WP_001095723.1 | MFS transporter | - |
| K6B66_RS11120 (2247825) | 2247825..2249333 | - | 1509 | WP_000199421.1 | FAD-dependent oxidoreductase | - |
| K6B66_RS11125 (2249378) | 2249378..2249866 | + | 489 | WP_001293633.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| K6B66_RS11130 (2250059) | 2250059..2251138 | + | 1080 | WP_000954705.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
| K6B66_RS11135 (2251190) | 2251190..2251471 | - | 282 | Protein_2182 | RidA family protein | - |
| K6B66_RS11140 (2251590) | 2251590..2251874 | - | 285 | WP_000221344.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6B66_RS11145 (2251864) | 2251864..2252112 | - | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6B66_RS11150 (2252412) | 2252412..2252870 | + | 459 | WP_000381836.1 | hypothetical protein | - |
| K6B66_RS11155 (2252864) | 2252864..2253196 | + | 333 | WP_000253166.1 | DUF1493 family protein | - |
| K6B66_RS11160 (2253360) | 2253360..2254310 | + | 951 | WP_000941990.1 | toll/interleukin-1 receptor domain-containing protein | - |
| K6B66_RS11165 (2254381) | 2254381..2254956 | - | 576 | Protein_2188 | helix-turn-helix domain-containing protein | - |
| K6B66_RS11170 (2255371) | 2255371..2256294 | - | 924 | WP_023230780.1 | hypothetical protein | - |
| K6B66_RS11175 (2256728) | 2256728..2256943 | - | 216 | WP_001530185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2250059..2259243 | 9184 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11015.73 Da Isoelectric Point: 10.5388
>T213553 WP_000221344.1 NZ_CP081858:c2251874-2251590 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
Download Length: 285 bp
>T213553 NZ_CP109651:522416-522766 [Bacillus safensis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT213553 WP_000885424.1 NZ_CP081858:c2252112-2251864 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT213553 NZ_CP109651:522130-522411 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1ICX1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I0WPN5 |