Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 508083..508633 Replicon chromosome
Accession NZ_CP081858
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag K6B66_RS02375 Protein ID WP_001199743.1
Coordinates 508325..508633 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag K6B66_RS02370 Protein ID WP_000016243.1
Coordinates 508083..508322 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6B66_RS02340 (503351) 503351..504115 - 765 WP_000998688.1 gluconate 5-dehydrogenase -
K6B66_RS02345 (504140) 504140..505171 - 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
K6B66_RS02350 (505388) 505388..505918 + 531 WP_000896756.1 gluconokinase -
K6B66_RS02355 (505946) 505946..506965 - 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
K6B66_RS02365 (507750) 507750..507974 + 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
K6B66_RS02370 (508083) 508083..508322 + 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
K6B66_RS02375 (508325) 508325..508633 + 309 WP_001199743.1 CcdB family protein Toxin
K6B66_RS23565 (509055) 509055..509356 + 302 Protein_455 Arm DNA-binding domain-containing protein -
K6B66_RS02385 (509718) 509718..513233 + 3516 WP_000342548.1 AAA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T213551 WP_001199743.1 NZ_CP081858:508325-508633 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T213551 NZ_CP109619:2368116-2368397 [Treponema denticola]
ATGAAATACGAAATAAAATTTACAAACCAATTTAAGAAAGATATTAAACTTGCAAAAAAACAGAATAAAAACTTAGATAA
GTTATTGAAAGTTATTGATTTACTTTCAAATGGAGAAAAACTTGAAGCTAAGTATAGAGATCATGATTTATCAGGAAACT
ATAAGGGAACAAGAGAATGTCACATAGAACCGGATTGGCTTTTAGTATATGAAATTAGAAATGATGTACTCGTACTTATG
CTTTATAGACTTGGCTCACATTCAGAGCTTTTTAAAAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT213551 WP_000016243.1 NZ_CP081858:508083-508322 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT213551 NZ_CP109619:2367847-2368119 [Treponema denticola]
ATGGCAACAACAAATTTGAATATCAGAACAGATAAAGAAATGAAGGAGCGAGCAGAAGCTATTTTTTTTGAGTTAGGGCT
TAATATGACAACGGCTATCAATATATTTTTAAGAACAACTATTAGAGAAAATGGAATCCCGTTTGCTTTGAAATTAGATA
TTCCCAATGCAATTACAGCGTCGGCAATAGAAGAAGGTAGAAAAATTGCTTATGATGATACCGTAAAAAAATATTCAAAT
ATAGACGATTTGCGGAAAGCACTGGAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References