Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 467490..468006 Replicon chromosome
Accession NZ_CP081858
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K6B66_RS02170 Protein ID WP_000220578.1
Coordinates 467722..468006 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K6B66_RS02165 Protein ID WP_000212724.1
Coordinates 467490..467732 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6B66_RS02145 (462510) 462510..463643 + 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -
K6B66_RS02150 (463627) 463627..464745 + 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K6B66_RS02155 (464742) 464742..465482 + 741 WP_000779262.1 KDGP aldolase family protein -
K6B66_RS02160 (465499) 465499..467412 + 1914 WP_001212145.1 BglG family transcription antiterminator -
K6B66_RS02165 (467490) 467490..467732 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6B66_RS02170 (467722) 467722..468006 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6B66_RS02175 (468010) 468010..468474 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6B66_RS02180 (468691) 468691..470829 - 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
K6B66_RS02185 (471238) 471238..472890 - 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T213550 WP_000220578.1 NZ_CP081858:467722-468006 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T213550 NZ_CP109619:1811881-1812189 [Treponema denticola]
ATGAGAATTATAGAAACGCCTGTTTTCACAAAACAAATAAATAGGCTACTGGACGAAGATACATATAAACAATTTAAAGA
ATATCTAGTATGTAATCCATTGAAAGGTAAATTGATTAAGGGTGGCGGCGGAATACGAAAAATAAGATGGAGCAAAAAGA
ATACCGGAAAAAGCGGCGGTATTAGGATTATTTATTTTATAAAAACTGAAACAAAGATATATTTGTTGTTTGCTTATTCA
AAAAGTGATGCAGAGAGCATTACAAAAAAACAAATAAATATGTTGGCAAGTTTTATTAAAGGTTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT213550 WP_000212724.1 NZ_CP081858:467490-467732 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT213550 NZ_CP109619:1812199-1812507 [Treponema denticola]
ATGTTTAAAAGAAAAAAAATGAGTGATGAGATGTTTGCCGAATTACTCCAAAGCGTAAAGGAAGCTGTTTTAATTGAAAA
AGGAGAAATTCCCCCCTCCAGAATTTTTGAAATCGAGCCTTTGGATATTGCCAAAATACGCAGTAAGACAAATAAAACAC
AAGAAGAATTTGCATCTATGCTTAATATCAGTATCGGTACCTTACGAAACTGGGAACAAGGCAGGCGTAAGCCTGATGGG
GCGGCCTTGTCTCTACTTAAAATCGTTTCGGCTAATCCTCAATATGTAGAAAGCGTGCTGCAGGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References