Detailed information of TA system TA213549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 352361..353142
• Replicon: chromosome
• Accession: NZ_CP081858
• Organism: Salmonella enterica subsp. enterica serovar Schwarzengrund strain S16

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A752VN12
• Locus tag: K6B66_RS01545
• Protein ID: WP_000622305.1
• Coordinates: 352651..353142 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3V4SIN7
• Locus tag: K6B66_RS01540
• Protein ID: WP_001110453.1
• Coordinates: 352361..352654 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6B66_RS01520 (348661)	348661..349566	+	906	WP_001268205.1	YjiK family protein	-
K6B66_RS23535 (349861)	349861..349995	-	135	Protein_285	hypothetical protein	-
K6B66_RS23540 (350105)	350105..350204	-	100	Protein_286	hypothetical protein	-
K6B66_RS23545 (350224)	350224..350406	+	183	WP_001527266.1	ATP-binding cassette domain-containing protein	-
K6B66_RS01530 (350399)	350399..350686	-	288	WP_001269916.1	transcriptional regulator RtsB	-
K6B66_RS01535 (350683)	350683..351558	-	876	WP_000921676.1	AraC family transcriptional regulator	-
K6B66_RS23550 (351822)	351822..352044	-	223	Protein_290	hypothetical protein	-
K6B66_RS01540 (352361)	352361..352654	+	294	WP_001110453.1	DUF1778 domain-containing protein	Antitoxin
K6B66_RS01545 (352651)	352651..353142	+	492	WP_000622305.1	GNAT family N-acetyltransferase	Toxin
K6B66_RS01550 (353377)	353377..353610	+	234	Protein_293	IS481 family transposase	-
K6B66_RS01555 (353885)	353885..354112	-	228	WP_001112995.1	hypothetical protein	-
K6B66_RS01560 (354701)	354701..354985	+	285	WP_192917775.1	PapB/FocB family fimbrial expression transcriptional regulator	-
K6B66_RS01565 (355020)	355020..355559	+	540	WP_000721295.1	type 1 fimbrial protein	-
K6B66_RS01570 (355569)	355569..358007	+	2439	WP_001014136.1	F4 (K88) fimbrial usher FaeD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeC / faeD / faeE / faeF / faeH / faeI	350399..365648	15249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17606.43 Da
• Isoelectric Point: 7.7297

>T213549 WP_000622305.1 NZ_CP081858:352651-353142 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T213549 NZ_CP109619:4876-5157 [Treponema denticola]
ATGATATATCAATTAAAGAAAACATCTCAGTTTAAAGCAAGTGTCAAATTGGCAAAGAAAAGAGGTTTGAATATTAATCT
TCTTGAAGGTATCATAGAAAAATTAAGGACAGATACGCCGCTTGGGGTAAAACATAAAAATCACCAACTTTCAGGACAGT
TTAAAGGTATTTGGGAGTGTCACATACAACCTGATTGGTTATTATTATATTTAAAAGAAGAAAACAATTTAGTTATGACT
CTTGTTGATACGGGAACACATAGCGATATTTTTAAGAAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10948.57 Da
• Isoelectric Point: 9.8590

>AT213549 WP_001110453.1 NZ_CP081858:352361-352654 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT213549 NZ_CP109619:4601-4879 [Treponema denticola]
ATGTCCACTGCAGTATTACAAACGCGAGTTGATAGTCAAATAAAAAAAGAAGCTGATGATCTTTTTAATGCATTAGGTAT
TGATACAACAACTGCAATTCGATTATTTTTAAAGCAAGCTATAAATCAGCAAAAAATTCCTTTTGAAATTCTGCCTCCAC
AAAAAGAATTTTCACCATCTGTTTTAGCCGCGATAAAAGAAGCAAGACAAATCAGTTGTGATGCTTCGGTTAAACAGTAT
AAAACTGCAAAAGAATTGCTTGCGGATTGTGAAGTATGA

Structures

Toxin

• AlphaFold DB: A0A752VN12

Antitoxin

• AlphaFold DB: A0A3V4SIN7