Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 787653..788299 Replicon plasmid p29362-2
Accession NZ_CP081849
Organism Polymorphobacter megasporae strain PAMC 29362

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KTC28_RS21815 Protein ID WP_216711222.1
Coordinates 787653..788042 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KTC28_RS21820 Protein ID WP_216711223.1
Coordinates 788042..788299 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC28_RS21795 (KTC28_21795) 782823..783113 - 291 WP_216711218.1 helix-turn-helix transcriptional regulator -
KTC28_RS21800 (KTC28_21800) 783130..784389 - 1260 WP_216711219.1 tyrosine-type recombinase/integrase -
KTC28_RS21805 (KTC28_21805) 784386..785765 - 1380 WP_216711220.1 site-specific integrase -
KTC28_RS21810 (KTC28_21810) 786791..787336 - 546 WP_216711221.1 hypothetical protein -
KTC28_RS21815 (KTC28_21815) 787653..788042 - 390 WP_216711222.1 type II toxin-antitoxin system VapC family toxin Toxin
KTC28_RS21820 (KTC28_21820) 788042..788299 - 258 WP_216711223.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KTC28_RS21825 (KTC28_21825) 788955..789884 - 930 WP_216711224.1 LysR family transcriptional regulator -
KTC28_RS21830 (KTC28_21830) 790002..790700 + 699 WP_216711225.1 pirin family protein -
KTC28_RS21835 (KTC28_21835) 790899..791315 + 417 WP_216711226.1 DoxX family protein -
KTC28_RS21840 (KTC28_21840) 791418..791858 - 441 WP_216711227.1 nuclear transport factor 2 family protein -
KTC28_RS21845 (KTC28_21845) 791951..792517 - 567 WP_255602654.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..906785 906785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-84)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13895.84 Da        Isoelectric Point: 6.2305

>T213546 WP_216711222.1 NZ_CP081849:c788042-787653 [Polymorphobacter megasporae]
MVIDSSALMAILRREPEEQDFRNAIKLAASRLISASTRVEVGIVALGRAGEAGLEQLQALLDTLRVETVPVSADHASLAI
DAFRRFGKGRHPAGLNFGDCFSYALAKATGEPLLFKGQDFSHTDIERAA

Download         Length: 390 bp

>T213546 NZ_CP109614:c5153484-5153101 [Klebsiella sp. KP20-425-1]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9583.72 Da        Isoelectric Point: 4.5393

>AT213546 WP_216711223.1 NZ_CP081849:c788299-788042 [Polymorphobacter megasporae]
MALSLKDRETDSLARQVASLTGETLTEAVRGALRLRLRDEQLKRGERPWDDAAIDAIIERFNALPLLDHRTDDDILGYDE
HGLPS

Download         Length: 258 bp

>AT213546 NZ_CP109614:c5153726-5153484 [Klebsiella sp. KP20-425-1]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References