Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3156369..3156886 Replicon chromosome
Accession NZ_CP081848
Organism Polymorphobacter megasporae strain PAMC 29362

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KTC28_RS14760 Protein ID WP_216707898.1
Coordinates 3156369..3156635 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KTC28_RS14765 Protein ID WP_216707899.1
Coordinates 3156632..3156886 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC28_RS14735 (KTC28_14735) 3151531..3151947 + 417 WP_216707893.1 hypothetical protein -
KTC28_RS14740 (KTC28_14740) 3152050..3152316 - 267 WP_216707894.1 hypothetical protein -
KTC28_RS14745 (KTC28_14745) 3152523..3153281 + 759 WP_216707895.1 sterol desaturase family protein -
KTC28_RS14750 (KTC28_14750) 3153474..3155339 + 1866 WP_216707896.1 phosphomethylpyrimidine synthase ThiC -
KTC28_RS14755 (KTC28_14755) 3155350..3156330 + 981 WP_216707897.1 HNH endonuclease signature motif containing protein -
KTC28_RS14760 (KTC28_14760) 3156369..3156635 - 267 WP_216707898.1 Txe/YoeB family addiction module toxin Toxin
KTC28_RS14765 (KTC28_14765) 3156632..3156886 - 255 WP_216707899.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KTC28_RS14770 (KTC28_14770) 3156927..3157259 - 333 WP_216707900.1 helix-turn-helix transcriptional regulator -
KTC28_RS14775 (KTC28_14775) 3157509..3158672 + 1164 WP_216707901.1 hypothetical protein -
KTC28_RS14780 (KTC28_14780) 3159021..3160232 + 1212 WP_216707902.1 autotransporter outer membrane beta-barrel domain-containing protein -
KTC28_RS14785 (KTC28_14785) 3160357..3161610 - 1254 WP_216707903.1 ATP-dependent Clp protease ATP-binding subunit ClpX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10364.81 Da        Isoelectric Point: 9.5776

>T213545 WP_216707898.1 NZ_CP081848:c3156635-3156369 [Polymorphobacter megasporae]
VKVTFDADAWTEYLTWVDEDRKVLARINALIAECRRDPFRGTGKPEPLKRNLTGWWSRRITTEHRLVYRVRGAGEGQALE
VLSCRYHY

Download         Length: 267 bp

>T213545 NZ_CP109614:c4829792-4828917 [Klebsiella sp. KP20-425-1]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9292.60 Da        Isoelectric Point: 4.3085

>AT213545 WP_216707899.1 NZ_CP081848:c3156886-3156632 [Polymorphobacter megasporae]
MYALSFSETRANLKAVMDRVVADRAPVVITRQRGESVVMVAQSDWEAMEETLYLLSSPANAKQLMDGIARLDAGLGEEHE
LIEP

Download         Length: 255 bp

>AT213545 NZ_CP109614:c4830598-4829840 [Klebsiella sp. KP20-425-1]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References