Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 611252..611996 Replicon chromosome
Accession NZ_CP081848
Organism Polymorphobacter megasporae strain PAMC 29362

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KTC28_RS02850 Protein ID WP_255602213.1
Coordinates 611252..611653 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KTC28_RS02855 Protein ID WP_216709638.1
Coordinates 611715..611996 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC28_RS02830 (KTC28_02830) 606458..607492 - 1035 WP_216709635.1 right-handed parallel beta-helix repeat-containing protein -
KTC28_RS02835 (KTC28_02835) 608097..609629 - 1533 WP_255602212.1 replicative DNA helicase -
KTC28_RS02840 (KTC28_02840) 609733..610410 + 678 WP_216709636.1 pyrimidine 5'-nucleotidase -
KTC28_RS02845 (KTC28_02845) 610407..611255 + 849 WP_216709637.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
KTC28_RS02850 (KTC28_02850) 611252..611653 - 402 WP_255602213.1 type II toxin-antitoxin system VapC family toxin Toxin
KTC28_RS02855 (KTC28_02855) 611715..611996 - 282 WP_216709638.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTC28_RS02860 (KTC28_02860) 612046..612591 - 546 WP_255602214.1 TlpA disulfide reductase family protein -
KTC28_RS02865 (KTC28_02865) 612644..613969 + 1326 WP_216709640.1 argininosuccinate lyase -
KTC28_RS02870 (KTC28_02870) 613966..614193 + 228 WP_216709641.1 hypothetical protein -
KTC28_RS02875 (KTC28_02875) 614193..615461 + 1269 WP_216709642.1 diaminopimelate decarboxylase -
KTC28_RS02880 (KTC28_02880) 615516..616388 + 873 WP_216709802.1 UTP--glucose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(13-73)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14576.62 Da        Isoelectric Point: 7.8610

>T213544 WP_255602213.1 NZ_CP081848:c611653-611252 [Polymorphobacter megasporae]
VQSWSKAQAGPTVYISVLSLAEFDKGIANLSDEDFRRAIIATQCANLAANFAGRILPVSDEVACRWGTISGRIKRDTGHP
PPVIDMLLAATAIEHDLYLVTRNVRDVRLSGAAVFNPWDDDPASMVLSARRRR

Download         Length: 402 bp

>T213544 NZ_CP109614:c4669462-4669178 [Klebsiella sp. KP20-425-1]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10566.01 Da        Isoelectric Point: 4.7187

>AT213544 WP_216709638.1 NZ_CP081848:c611996-611715 [Polymorphobacter megasporae]
MTIQTRVESADPVWKLEDAKARFSEVVRLARDVGPQRVTVRGRPAVVVVAADEYDRLSPPVKPRSLFDMLQGLTELGELE
IERDRDTGRDIEF

Download         Length: 282 bp

>AT213544 NZ_CP109614:c4669694-4669452 [Klebsiella sp. KP20-425-1]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References