Detailed information of TA system TA213542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2946781..2947364
• Replicon: chromosome
• Accession: NZ_CP081844
• Organism: Caenibius sp. WL

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K5X80_RS14115
• Protein ID: WP_222558346.1
• Coordinates: 2946781..2947035 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K5X80_RS14120
• Protein ID: WP_222558347.1
• Coordinates: 2947032..2947364 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5X80_RS14070 (K5X80_14060)	2941783..2942007	+	225	WP_222558337.1	hypothetical protein	-
K5X80_RS14075 (K5X80_14065)	2942018..2942341	-	324	WP_222558338.1	hypothetical protein	-
K5X80_RS14080 (K5X80_14070)	2942392..2942985	+	594	WP_222558339.1	SOS response-associated peptidase family protein	-
K5X80_RS14085 (K5X80_14075)	2942971..2943399	-	429	WP_222558340.1	hypothetical protein	-
K5X80_RS14090 (K5X80_14080)	2943772..2944146	-	375	WP_222558341.1	hypothetical protein	-
K5X80_RS14095 (K5X80_14085)	2944214..2944582	-	369	WP_222558342.1	hypothetical protein	-
K5X80_RS14100 (K5X80_14090)	2944579..2945130	-	552	WP_222558343.1	glycosyl hydrolase 108 family protein	-
K5X80_RS14105 (K5X80_14095)	2945132..2945422	-	291	WP_222558344.1	hypothetical protein	-
K5X80_RS14110 (K5X80_14100)	2945404..2946690	-	1287	WP_222558345.1	hypothetical protein	-
K5X80_RS14115 (K5X80_14105)	2946781..2947035	+	255	WP_222558346.1	type II toxin-antitoxin system HicA family toxin	Toxin
K5X80_RS14120 (K5X80_14110)	2947032..2947364	+	333	WP_222558347.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K5X80_RS14125 (K5X80_14115)	2947475..2950015	-	2541	WP_222558348.1	hypothetical protein	-
K5X80_RS14130 (K5X80_14120)	2950294..2951058	-	765	WP_222558349.1	hypothetical protein	-
K5X80_RS14135 (K5X80_14125)	2951090..2952064	-	975	WP_222558350.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2942392..2979384	36992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-77)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9339.79 Da
• Isoelectric Point: 9.9740

>T213542 WP_222558346.1 NZ_CP081844:2946781-2947035 [Caenibius sp. WL]
MNSKQSKTLKAIFSDPVSGTIKWASIESLFVAVGCEIIEGKGSHVQAHKDGVIGYFVRPHPNKEAKRYQIRDVREFLAKI
GVEP

Nucleotide

• Length: 255 bp

>T213542 NZ_CP109614:3931775-3931993 [Klebsiella sp. KP20-425-1]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12245.75 Da
• Isoelectric Point: 5.1687

>AT213542 WP_222558347.1 NZ_CP081844:2947032-2947364 [Caenibius sp. WL]
MNVMSHKGYSARIEYDDDDGIFFGRLAGINDVVGFHADSVEELRAAFHEAVDDYIEACAKIGKDPQKPYSGKMMFRVSPE
LHRRAAIAAELAGKSLNQWAEEALHEALPH

Nucleotide

• Length: 333 bp

>AT213542 NZ_CP109614:3931374-3931748 [Klebsiella sp. KP20-425-1]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG