Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 6572..7065 Replicon plasmid pBN31-16k
Accession NZ_CP081835
Organism Vagococcus lutrae strain BN31

Toxin (Protein)


Gene name relE Uniprot ID V6Q3V2
Locus tag K5X77_RS10115 Protein ID WP_023606340.1
Coordinates 6572..6847 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6Q580
Locus tag K5X77_RS10120 Protein ID WP_023606341.1
Coordinates 6844..7065 (-) Length 74 a.a.

Genomic Context

K5X77_RS10110K5X77_RS10125K5X77_RS10075K5X77_RS10080K5X77_RS10085K5X77_RS10090K5X77_RS10095K5X77_RS10100K5X77_RS10105K5X77_RS10115K5X77_RS10120K5X77_RS10130K5X77_RS10135K5X77_RS10140K5X77_RS10145
Location: 5905..6534 (630 bp)
Type: Others
Protein ID: WP_222319404.1
Location: 7977..8270 (294 bp)
Type: Others
Protein ID: WP_222319406.1
Location: 1726..2115 (390 bp)
Type: Others
Protein ID: WP_222319392.1
Location: 2126..2620 (495 bp)
Type: Others
Protein ID: WP_222319394.1
Location: 2728..3672 (945 bp)
Type: Others
Protein ID: WP_222319396.1
Location: 3693..4646 (954 bp)
Type: Others
Protein ID: WP_222319398.1
Location: 4661..5197 (537 bp)
Type: Others
Protein ID: WP_222319400.1
Location: 5319..5486 (168 bp)
Type: Others
Protein ID: WP_222319402.1
Location: 5527..5727 (201 bp)
Type: Others
Protein ID: WP_246616582.1
Location: 6572..6847 (276 bp)
Type: Toxin
Protein ID: WP_023606340.1
Location: 6844..7065 (222 bp)
Type: Antitoxin
Protein ID: WP_023606341.1
Location: 8658..9578 (921 bp)
Type: Others
Protein ID: WP_222319364.1
Location: 9606..10142 (537 bp)
Type: Others
Protein ID: WP_222319366.1
Location: 10149..10898 (750 bp)
Type: Others
Protein ID: WP_172442040.1
Location: 11252..11815 (564 bp)
Type: Others
Protein ID: WP_222319368.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5X77_RS10075 (K5X77_10075)1726..2115-390WP_222319392.1hypothetical protein-
K5X77_RS10080 (K5X77_10080)2126..2620-495WP_222319394.1hypothetical protein-
K5X77_RS10085 (K5X77_10085)2728..3672-945WP_222319396.1DnaA/Hda family protein-
K5X77_RS10090 (K5X77_10090)3693..4646-954WP_222319398.1GntR family transcriptional regulator-
K5X77_RS10095 (K5X77_10095)4661..5197-537WP_222319400.1hypothetical protein-
K5X77_RS10100 (K5X77_10100)5319..5486-168WP_222319402.1hypothetical protein-
K5X77_RS10105 (K5X77_10105)5527..5727-201WP_246616582.1transcriptional regulator-
K5X77_RS10110 (K5X77_10110)5905..6534+630WP_222319404.1helix-turn-helix transcriptional regulator-
K5X77_RS10115 (K5X77_10115)6572..6847-276WP_023606340.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K5X77_RS10120 (K5X77_10120)6844..7065-222WP_023606341.1DUF6290 family proteinAntitoxin
K5X77_RS10125 (K5X77_10125)7977..8270+294WP_222319406.1hypothetical protein-
K5X77_RS10130 (K5X77_10130)8658..9578-921WP_222319364.1Abi family protein-
K5X77_RS10135 (K5X77_10135)9606..10142-537WP_222319366.1hypothetical protein-
K5X77_RS10140 (K5X77_10140)10149..10898-750WP_172442040.1replication initiation protein-
K5X77_RS10145 (K5X77_10145)11252..11815-564WP_222319368.1recombinase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..1615916159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-90)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10753.42 Da        Isoelectric Point: 10.4608

>T213541 WP_023606340.1 NZ_CP081835:c6847-6572 [Vagococcus lutrae]
MTQKKYTVRYEKNAQKALKKMDKHQAGLIMSWISKNLNETEFPRHHGKALAGNKSGQWRYRVGDYRIIAHIDDDTITILV
LEIGHRREIYK

Download         Length: 276 bp

>T213541 NZ_CP109614:c2622899-2621577 [Klebsiella sp. KP20-425-1]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8357.54 Da        Isoelectric Point: 4.2925

>AT213541 WP_023606341.1 NZ_CP081835:c7065-6844 [Vagococcus lutrae]
MSNVTFRVTDEEKKFMQSMAELNGLSLSELARTKLLEALEDQIDIGLYEKAMKAHELKDESISHEEMLQELGL

Download         Length: 222 bp

>AT213541 NZ_CP109614:c2623165-2622899 [Klebsiella sp. KP20-425-1]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV6Q3V2

Antitoxin

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Source
ID
Structure
AlphaFold DBV6Q580

References