Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 9114..10281 Replicon plasmid pBN31-cfrD
Accession NZ_CP081834
Organism Vagococcus lutrae strain BN31

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag K5X77_RS09905 Protein ID WP_222319359.1
Coordinates 9388..10281 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag K5X77_RS09900 Protein ID WP_002333002.1
Coordinates 9114..9386 (+) Length 91 a.a.

Genomic Context

K5X77_RS09870K5X77_RS09875K5X77_RS09880K5X77_RS09885K5X77_RS09890K5X77_RS09895K5X77_RS09900K5X77_RS09905K5X77_RS09910K5X77_RS09920K5X77_RS09935K5X77_RS09940K5X77_RS09915K5X77_RS09925K5X77_RS09930
Location: 6127..6366 (240 bp)
Type: Others
Protein ID: WP_002425012.1
Location: 6430..6498 (69 bp)
Type: Others
Protein ID: WP_011100846.1
Location: 6623..7360 (738 bp)
Type: Others
Protein ID: WP_032495453.1
Location: 7530..7790 (261 bp)
Type: Others
Protein ID: Protein_9
Location: 7893..8789 (897 bp)
Type: Others
Protein ID: WP_222319357.1
Location: 8881..9096 (216 bp)
Type: Others
Protein ID: WP_001835296.1
Location: 9114..9386 (273 bp)
Type: Antitoxin
Protein ID: WP_002333002.1
Location: 9388..10281 (894 bp)
Type: Toxin
Protein ID: WP_222319359.1
Location: 10319..10999 (681 bp)
Type: Others
Protein ID: WP_044291606.1
Location: 11789..12862 (1074 bp)
Type: Others
Protein ID: WP_216807377.1
Location: 14494..14598 (105 bp)
Type: Others
Protein ID: Protein_19
Location: 14615..14887 (273 bp)
Type: Others
Protein ID: WP_005237730.1
Location: 11033..11344 (312 bp)
Type: Others
Protein ID: WP_172443271.1
Location: 12946..13680 (735 bp)
Type: Others
Protein ID: Protein_17
Location: 13743..14423 (681 bp)
Type: Others
Protein ID: WP_044291606.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K5X77_RS09870 (K5X77_09870)6127..6366+240WP_002425012.1peptide-binding protein-
K5X77_RS09875 (K5X77_09875)6430..6498+69WP_011100846.123S rRNA methyltransferase attenuator leader peptide ErmL-
K5X77_RS09880 (K5X77_09880)6623..7360+738WP_032495453.123S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)-
K5X77_RS09885 (K5X77_09885)7530..7790+261Protein_9topoisomerase DNA-binding C4 zinc finger domain-containing protein-
K5X77_RS09890 (K5X77_09890)7893..8789+897WP_222319357.1ParA family protein-
K5X77_RS09895 (K5X77_09895)8881..9096+216WP_001835296.1peptide-binding protein-
K5X77_RS09900 (K5X77_09900)9114..9386+273WP_002333002.1antitoxinAntitoxin
K5X77_RS09905 (K5X77_09905)9388..10281+894WP_222319359.1zeta toxin family proteinToxin
K5X77_RS09910 (K5X77_09910)10319..10999+681WP_044291606.1IS6-like element IS1216 family transposase-
K5X77_RS09915 (K5X77_09915)11033..11344-312WP_172443271.1helix-turn-helix domain-containing protein-
K5X77_RS09920 (K5X77_09920)11789..12862+1074WP_216807377.1Cfr family 23S rRNA (adenine(2503)-C(8))-methyltransferase-
K5X77_RS09925 (K5X77_09925)12946..13680-735Protein_17glutamine-hydrolyzing GMP synthase-
K5X77_RS09930 (K5X77_09930)13743..14423-681WP_044291606.1IS6-like element IS1216 family transposase-
K5X77_RS09935 (K5X77_09935)14494..14598+105Protein_19peptide-binding protein-
K5X77_RS09940 (K5X77_09940)14615..14887+273WP_005237730.1antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmiderm(B) / Cfr(D)-1..3348533485
-insideIScluster/Tnerm(B) / Cfr(D)-6623..144297806


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 33516.29 Da        Isoelectric Point: 8.2780

>T213539 WP_222319359.1 NZ_CP081834:9388-10281 [Vagococcus lutrae]
MANIVNFTDKQFENRLSDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDKGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIAVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKISGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPAIPKTPKLPGVLLQSFKSTIK

Download         Length: 894 bp

>T213539 NZ_CP109614:1466980-1467462 [Klebsiella sp. KP20-425-1]
GTGGGACGTGTAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTTGA
TGAATGGCTAAAGCACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAACTACAGGCAGACTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCCGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT213539 WP_002333002.1 NZ_CP081834:9114-9386 [Vagococcus lutrae]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT213539 NZ_CP109614:1466726-1466992 [Klebsiella sp. KP20-425-1]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCTTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2Z6BWJ3

References