Detailed information of TA system TA213533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4767917..4768388
• Replicon: chromosome
• Accession: NZ_CP081827
• Organism: Klebsiella quasipneumoniae strain AR8538

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K5P22_RS22915
• Protein ID: WP_023291758.1
• Coordinates: 4767917..4768156 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: K5P22_RS22920
• Protein ID: WP_023291757.1
• Coordinates: 4768146..4768388 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5P22_RS22905 (4764870)	4764870..4767008	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
K5P22_RS22910 (4767404)	4767404..4767868	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
K5P22_RS22915 (4767917)	4767917..4768156	-	240	WP_023291758.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5P22_RS22920 (4768146)	4768146..4768388	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K5P22_RS22925 (4768466)	4768466..4770376	-	1911	WP_249481500.1	PRD domain-containing protein	-
K5P22_RS22930 (4770399)	4770399..4771550	-	1152	WP_249481501.1	lactonase family protein	-
K5P22_RS22935 (4771617)	4771617..4772357	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-79)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9162.72 Da
• Isoelectric Point: 10.1315

>T213533 WP_023291758.1 NZ_CP081827:c4768156-4767917 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Nucleotide

• Length: 240 bp

>T213533 NZ_CP109612:c55077-54736 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGTTGGAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACAATGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCCACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGATTTTACAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT213533 WP_023291757.1 NZ_CP081827:c4768388-4768146 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT213533 NZ_CP109612:c55307-55077 [Enterococcus faecalis]
ATGTTAACAACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGATCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86