Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3468486..3469117 Replicon chromosome
Accession NC_007613
Organism Shigella boydii Sb227

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag SBO_RS19195 Protein ID WP_001259385.1
Coordinates 3468842..3469117 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag SBO_RS19190 Protein ID WP_000593554.1
Coordinates 3468486..3468845 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBO_RS19165 3464618..3465562 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
SBO_RS19170 3465559..3466392 + 834 WP_001008950.1 nickel ABC transporter permease subunit NikC -
SBO_RS19175 3466392..3467156 + 765 WP_001136224.1 nickel import ATP-binding protein NikD -
SBO_RS19180 3467153..3467959 + 807 WP_000173706.1 nickel import ATP-binding protein NikE -
SBO_RS19185 3467965..3468366 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
SBO_RS19190 3468486..3468845 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SBO_RS19195 3468842..3469117 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
SBO_RS19200 3469190..3470314 - 1125 WP_001216257.1 ABC transporter permease -
SBO_RS19205 3470314..3473049 - 2736 WP_000149139.1 ribosome-associated ATPase/putative transporter RbbA -
SBO_RS19210 3473046..3474113 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T21353 WP_001259385.1 NC_007613:c3469117-3468842 [Shigella boydii Sb227]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T21353 NC_007613:c3469117-3468842 [Shigella boydii Sb227]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT21353 WP_000593554.1 NC_007613:c3468845-3468486 [Shigella boydii Sb227]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT21353 NC_007613:c3468845-3468486 [Shigella boydii Sb227]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References