Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 810030..810687 Replicon chromosome
Accession NZ_CP081827
Organism Klebsiella quasipneumoniae strain AR8538

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag K5P22_RS04020 Protein ID WP_023290968.1
Coordinates 810277..810687 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K5P22_RS04015 Protein ID WP_002916312.1
Coordinates 810030..810296 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P22_RS03990 (805189) 805189..806622 - 1434 WP_044524684.1 6-phospho-beta-glucosidase -
K5P22_RS03995 (806741) 806741..807469 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
K5P22_RS04000 (807520) 807520..807831 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
K5P22_RS04005 (807995) 807995..808654 + 660 WP_008806429.1 hemolysin III family protein -
K5P22_RS04010 (808801) 808801..809784 - 984 WP_044524683.1 tRNA-modifying protein YgfZ -
K5P22_RS04015 (810030) 810030..810296 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K5P22_RS04020 (810277) 810277..810687 + 411 WP_023290968.1 protein YgfX Toxin
K5P22_RS04025 (810694) 810694..811215 - 522 WP_004205324.1 flavodoxin FldB -
K5P22_RS04030 (811316) 811316..812212 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
K5P22_RS04035 (812235) 812235..812948 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5P22_RS04040 (812954) 812954..814687 + 1734 WP_044524681.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T213521 WP_023290968.1 NZ_CP081827:810277-810687 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213521 NZ_CP109609:61065-61370 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213521 WP_002916312.1 NZ_CP081827:810030-810296 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213521 NZ_CP109609:60845-61063 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References