Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 678010..678692 Replicon chromosome
Accession NZ_CP081827
Organism Klebsiella quasipneumoniae strain AR8538

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag K5P22_RS03345 Protein ID WP_249481548.1
Coordinates 678351..678692 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag K5P22_RS03340 Protein ID WP_047666955.1
Coordinates 678010..678330 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5P22_RS03295 (673366) 673366..674070 + 705 WP_047666967.1 WYL domain-containing protein -
K5P22_RS03300 (674070) 674070..674639 + 570 WP_047666965.1 hypothetical protein -
K5P22_RS03305 (674676) 674676..675128 + 453 WP_015699705.1 hypothetical protein -
K5P22_RS03310 (675125) 675125..675574 + 450 WP_047666962.1 IrmA family protein -
K5P22_RS03315 (675646) 675646..675876 + 231 WP_047666960.1 DUF905 domain-containing protein -
K5P22_RS03320 (675975) 675975..676796 + 822 WP_047666958.1 DUF932 domain-containing protein -
K5P22_RS03325 (676827) 676827..677270 + 444 WP_047666957.1 antirestriction protein -
K5P22_RS03330 (677279) 677279..677761 + 483 WP_249481547.1 RadC family protein -
K5P22_RS03335 (677770) 677770..677991 + 222 WP_016151535.1 DUF987 domain-containing protein -
K5P22_RS03340 (678010) 678010..678330 + 321 WP_047666955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K5P22_RS03345 (678351) 678351..678692 + 342 WP_249481548.1 TA system toxin CbtA family protein Toxin
K5P22_RS03355 (679054) 679054..679560 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
K5P22_RS03360 (679660) 679660..681501 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
K5P22_RS03365 (681721) 681721..683466 - 1746 WP_017899733.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 652152..678692 26540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12918.97 Da        Isoelectric Point: 9.6542

>T213520 WP_249481548.1 NZ_CP081827:678351-678692 [Klebsiella quasipneumoniae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRTRQAIGLLRRSRNNAVL

Download         Length: 342 bp

>T213520 NZ_CP109608:300428-300712 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTAGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12049.53 Da        Isoelectric Point: 6.6255

>AT213520 WP_047666955.1 NZ_CP081827:678010-678330 [Klebsiella quasipneumoniae]
MSSNVTWGLQRDNTPRLGARLVQEGNRLHYLADRASITGKLSDAECRRLDETFPHFISQMESMLTTDELNPRHAHCVTLY
HNGFTCEAETLGSCGYVYIAIYPTQR

Download         Length: 321 bp

>AT213520 NZ_CP109608:300190-300438 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGTACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTCAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCTGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References