Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3097403..3098057 Replicon chromosome
Accession NC_007613
Organism Shigella boydii Sb227

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag SBO_RS17165 Protein ID WP_000244777.1
Coordinates 3097650..3098057 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag SBO_RS17160 Protein ID WP_000354046.1
Coordinates 3097403..3097669 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBO_RS17135 3092572..3093315 + 744 Protein_3069 SDR family oxidoreductase -
SBO_RS17140 3093372..3094805 - 1434 WP_004986559.1 6-phospho-beta-glucosidase BglA -
SBO_RS17145 3094850..3095161 + 312 WP_001182983.1 N(4)-acetylcytidine aminohydrolase -
SBO_RS17150 3095325..3095984 + 660 WP_000250272.1 hemolysin III family protein -
SBO_RS17155 3096180..3097160 - 981 WP_000886094.1 tRNA-modifying protein YgfZ -
SBO_RS17160 3097403..3097669 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
SBO_RS17165 3097650..3098057 + 408 WP_000244777.1 toxin CptA Toxin
SBO_RS17170 3098097..3098618 - 522 WP_001055874.1 flavodoxin FldB -
SBO_RS17175 3098730..3099626 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SBO_RS17180 3099651..3100361 + 711 WP_000715205.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SBO_RS17185 3100367..3102100 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T21352 WP_000244777.1 NC_007613:3097650-3098057 [Shigella boydii Sb227]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T21352 NC_007613:3097650-3098057 [Shigella boydii Sb227]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGATTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT21352 WP_000354046.1 NC_007613:3097403-3097669 [Shigella boydii Sb227]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT21352 NC_007613:3097403-3097669 [Shigella boydii Sb227]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References