Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5058162..5059843 | Replicon | chromosome |
| Accession | NZ_CP081820 | ||
| Organism | Klebsiella pneumoniae strain F726925 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | K5O13_RS25035 | Protein ID | WP_002885155.1 |
| Coordinates | 5058162..5059079 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | K5O13_RS25040 | Protein ID | WP_004151732.1 |
| Coordinates | 5059085..5059843 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5O13_RS25015 (K5O13_25015) | 5053468..5054988 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| K5O13_RS25020 (K5O13_25020) | 5054985..5055983 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| K5O13_RS25025 (K5O13_25025) | 5056014..5056955 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| K5O13_RS25030 (K5O13_25030) | 5057030..5058037 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| K5O13_RS25035 (K5O13_25035) | 5058162..5059079 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| K5O13_RS25040 (K5O13_25040) | 5059085..5059843 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| K5O13_RS25045 (K5O13_25045) | 5059929..5060657 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| K5O13_RS25050 (K5O13_25050) | 5060930..5063077 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| K5O13_RS25055 (K5O13_25055) | 5063307..5063993 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T213506 WP_002885155.1 NZ_CP081820:c5059079-5058162 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T213506 NZ_CP109606:4579028-4579330 [Pseudomonas putida]
ATGAAGAAAATCGAATCCAGCAGTTTCAGACATTGGGTGACCGGCCTGCGGGACAGCAGCGCCAGAGCCCGCATCATTTC
TCGGATCAACCGGTTAATGGAGGGTTTACCTGGCGACGTATCTCCGGTTGGCCATGGCGTCAGTGAACTCAGGATTCACT
ACGGGCCTGGCTACCGGGTGTACTTCCATCAGACGGGCAACACTTTCGTCATTCTGTTATGTAGTGGCGACAAAAGCAGC
CAACAGCGTGACATCAAGGCAGCCCACCAGATTCTGCGTTCGTGGAGGATGCAAAATGACTGA
ATGAAGAAAATCGAATCCAGCAGTTTCAGACATTGGGTGACCGGCCTGCGGGACAGCAGCGCCAGAGCCCGCATCATTTC
TCGGATCAACCGGTTAATGGAGGGTTTACCTGGCGACGTATCTCCGGTTGGCCATGGCGTCAGTGAACTCAGGATTCACT
ACGGGCCTGGCTACCGGGTGTACTTCCATCAGACGGGCAACACTTTCGTCATTCTGTTATGTAGTGGCGACAAAAGCAGC
CAACAGCGTGACATCAAGGCAGCCCACCAGATTCTGCGTTCGTGGAGGATGCAAAATGACTGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT213506 WP_004151732.1 NZ_CP081820:c5059843-5059085 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT213506 NZ_CP109606:4579323-4579616 [Pseudomonas putida]
ATGACTGAAACCTTTTCCGAATTCGACCCCGCCGAGTACCTCACAACGCCCGAAGCAATCGCGCAGTTCATGACCGACGC
ACTTGAGACTGGCGATGCCGGCTATGTTGCCAAAGCGGTTGGCGTGGTGGCCCGTGCAAAGGGCATGAGCGAACTGGCCA
AAGAAACTGGCCTGTCTCGCGAACAGCTCTACCGCTCTTTCAGCGAGCACGGCAACCCGACCCTGAAGTCGTTCCTGACC
GTAATGAAGGCATTAGGCATAGACATGACGGCGCGCCCCCACCTTGCTGGCTGA
ATGACTGAAACCTTTTCCGAATTCGACCCCGCCGAGTACCTCACAACGCCCGAAGCAATCGCGCAGTTCATGACCGACGC
ACTTGAGACTGGCGATGCCGGCTATGTTGCCAAAGCGGTTGGCGTGGTGGCCCGTGCAAAGGGCATGAGCGAACTGGCCA
AAGAAACTGGCCTGTCTCGCGAACAGCTCTACCGCTCTTTCAGCGAGCACGGCAACCCGACCCTGAAGTCGTTCCTGACC
GTAATGAAGGCATTAGGCATAGACATGACGGCGCGCCCCCACCTTGCTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |