Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4901977..4902493 Replicon chromosome
Accession NZ_CP081820
Organism Klebsiella pneumoniae strain F726925

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K5O13_RS24235 Protein ID WP_002886902.1
Coordinates 4901977..4902261 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K5O13_RS24240 Protein ID WP_002886901.1
Coordinates 4902251..4902493 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O13_RS24210 (K5O13_24210) 4897461..4897769 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
K5O13_RS24215 (K5O13_24215) 4897854..4898027 + 174 WP_002886906.1 hypothetical protein -
K5O13_RS24220 (K5O13_24220) 4898030..4898773 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K5O13_RS24225 (K5O13_24225) 4899130..4901268 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K5O13_RS24230 (K5O13_24230) 4901509..4901973 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5O13_RS24235 (K5O13_24235) 4901977..4902261 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5O13_RS24240 (K5O13_24240) 4902251..4902493 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5O13_RS24245 (K5O13_24245) 4902571..4904481 - 1911 WP_004152270.1 PRD domain-containing protein -
K5O13_RS24250 (K5O13_24250) 4904504..4905658 - 1155 WP_002886900.1 lactonase family protein -
K5O13_RS24255 (K5O13_24255) 4905724..4906464 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T213505 WP_002886902.1 NZ_CP081820:c4902261-4901977 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213505 NZ_CP109606:c4278251-4277955 [Pseudomonas putida]
ATGGAAAAGAGAACGCCTCACTGCCCTTTGCATCGGCTGCAAGTGCTATTGAGCCAAGGGAAGGTACGTACCACCCAGGC
GGCGACCCTGGGAGCGCGGTCGCTTGGGCTAGGTCCCTATGACATGTTGGATGTTGTCCGCGGGCTATCGCCAGGTGACT
TCCATAAAAGTATGACGAGCTACAACGATCATCGTATTTGGCAGGATGTCTATCGGGCGCAAACCGCCGTAGGCAGGGTT
TACCTCAAGCTGACGGTGGTCGACGATCTGCTCATCCTATCTTTCAAGGAGCTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213505 WP_002886901.1 NZ_CP081820:c4902493-4902251 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213505 NZ_CP109606:c4277953-4277552 [Pseudomonas putida]
ATGAAATGTCCCCTATGTGGAGGAGCGGAGTTGGTTGCGCAGTCGCGAGACATGCCGTATCGCTACAAAGGTGAGGCGAC
CGTCATCCCGGACATCTTTGGTGACTACTGCCCGACGTGTGGCGAGGCGGTACTGGGCATGGACGAGGCCCAGCGTATGA
GTGATCTGATGACGGCGTTTGAGCGCAAGGTCAATGCAGCCGTTGTCGATCCCGGCTTCATTGCTGCCATGCGCAGAAAG
TTCGACCTCGACCAGCGTGAAGCGGGGGAAATCTTCGGTGGTGGGGTCAATGCGTTCTCCCGTTATGAAAACGGCAAGAC
CACCCCGCCAGTGGCGTTGGTGAAACTGCTCAAGCTGCTGGATCGCCATCCAGAACTCTTTGAGGAAGTGCGTACTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References