Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3320055..3320712 Replicon chromosome
Accession NZ_CP081816
Organism Klebsiella pneumoniae strain AR8416

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K5O16_RS17045 Protein ID WP_002916310.1
Coordinates 3320302..3320712 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K5O16_RS17040 Protein ID WP_002916312.1
Coordinates 3320055..3320321 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O16_RS17015 3315211..3316644 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K5O16_RS17020 3316763..3317491 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K5O16_RS17025 3317541..3317852 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K5O16_RS17030 3318016..3318675 + 660 WP_002916317.1 hemolysin III family protein -
K5O16_RS17035 3318826..3319809 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K5O16_RS17040 3320055..3320321 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K5O16_RS17045 3320302..3320712 + 411 WP_002916310.1 protein YgfX Toxin
K5O16_RS17050 3320719..3321240 - 522 WP_002916308.1 flavodoxin FldB -
K5O16_RS17055 3321341..3322237 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K5O16_RS17060 3322260..3322973 + 714 WP_130955456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5O16_RS17065 3322979..3324712 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213479 WP_002916310.1 NZ_CP081816:3320302-3320712 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213479 NZ_CP109603:c311350-311030 [Pseudomonas putida]
ATGCTGTTCACTGAAACTCCTCTGTTCACGAAGCGTGTGAAAGACCTCCTTGAGGATGACGAATACCGCCTTCTCCAGAT
CAGGCTGATGGCCCAACCTGACACTGGAGACCTGATTGAAGGAACCGGTGGGCTACGCAAGGTGCGCATCGCTGCTAATG
GGCATGGAAAACGCGGCGGAGCCAGGGTCATCTATTACCATTTCATTAGCAAATCACAGATTGCAATGCTCTACATCTAC
CCAAAGAACGAGCAGCCTGACTTGTCCGCTGAACAGCGAAAAGCCCTGAAAAAAATCATCGAAAACTGGAGGCATGCATG
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213479 WP_002916312.1 NZ_CP081816:3320055-3320321 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213479 NZ_CP109603:c311033-310746 [Pseudomonas putida]
ATGAGCCGATTCTTTGAAGAGCTGATGGAAAGCGTTCAGCAGATGGATGACATTGTCCAAGGAAGGCAGGTGCCCTCCCG
TGTATTCGAGGTCGATGCGCTGCAGGTCAGAAGCATCCGCAAGTCAACGGGCCTCTCTCAGGTTCGGTTTGCCGAGATGA
TCGATGTTCAGGTTGCGACCTTGCGTAACTGGGAGCAAGGTCGCAGAGAGCCTACTGGCCCCGCCAAAGCACTGCTGCGG
GCGATTCGCAACGACCCTGAACATGTACTCAAGGCCTTGGCGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References