Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 117441..118084 Replicon plasmid p1
Accession NZ_CP081815
Organism Klebsiella pneumoniae strain AR8416

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag K5O16_RS00615 Protein ID WP_014386165.1
Coordinates 117441..117857 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag K5O16_RS00620 Protein ID WP_032408893.1
Coordinates 117854..118084 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O16_RS00590 114061..114492 + 432 WP_004194235.1 conjugation system SOS inhibitor PsiB -
K5O16_RS00595 114489..115217 + 729 WP_114432394.1 plasmid SOS inhibition protein A -
K5O16_RS00600 115214..115540 + 327 WP_004152639.1 hypothetical protein -
K5O16_RS00605 115596..115970 + 375 WP_032408891.1 hypothetical protein -
K5O16_RS00610 116150..117118 - 969 WP_074422984.1 IS5-like element IS903B family transposase -
K5O16_RS00615 117441..117857 - 417 WP_014386165.1 PIN domain-containing protein Toxin
K5O16_RS00620 117854..118084 - 231 WP_032408893.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5O16_RS00625 118404..118838 + 435 WP_000103648.1 RidA family protein -
K5O16_RS00630 118843..119517 + 675 WP_014386166.1 DUF1028 domain-containing protein -
K5O16_RS00635 119533..120690 + 1158 WP_038807146.1 acetylornithine deacetylase -
K5O16_RS00640 120861..122009 + 1149 WP_014386168.1 ABC transporter ATP-binding protein -
K5O16_RS00645 122028..123011 + 984 WP_001471744.1 NAD(P)H-quinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..180897 180897
- flank IS/Tn - - 116150..117073 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15127.44 Da        Isoelectric Point: 7.8841

>T213473 WP_014386165.1 NZ_CP081815:c117857-117441 [Klebsiella pneumoniae]
MTKTYMLDTNICSYIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGAIGKRASPRHVQLVDAFCARLDAILAWDRA
AVDATTEVKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVAGLTFEDWVQ

Download         Length: 417 bp

>T213473 NZ_CP109601:c4030129-4029842 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8854.89 Da        Isoelectric Point: 4.5112

>AT213473 WP_032408893.1 NZ_CP081815:c118084-117854 [Klebsiella pneumoniae]
MRTVSVFRNGNNRAIRLPRDLDFDGVNELEIIREGDTLILRPVKPSWSSFRQEEKADADFMAERENVVSDEGRFEL

Download         Length: 231 bp

>AT213473 NZ_CP109601:c4029855-4029553 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References