Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 836317..836836 Replicon chromosome
Accession NZ_CP081791
Organism Escherichia coli strain CT01

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag J6O14_RS04185 Protein ID WP_000277490.1
Coordinates 836552..836836 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag J6O14_RS04180 Protein ID WP_000124732.1
Coordinates 836317..836559 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O14_RS04165 (832737) 832737..833951 - 1215 WP_005012528.1 type II site-specific deoxyribonuclease -
J6O14_RS04170 (834063) 834063..834767 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
J6O14_RS04175 (834773) 834773..835744 + 972 WP_202195906.1 plasmid replication initiator RepA -
J6O14_RS04180 (836317) 836317..836559 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J6O14_RS04185 (836552) 836552..836836 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6O14_RS04190 (836974) 836974..837066 - 93 Protein_823 plasmid partition protein ParG -
J6O14_RS04195 (837386) 837386..837604 - 219 Protein_824 IS110 family transposase -
J6O14_RS04200 (837605) 837605..837904 - 300 Protein_825 glycogen/starch synthase -
J6O14_RS04205 (837904) 837904..839202 - 1299 WP_053287384.1 glucose-1-phosphate adenylyltransferase -
J6O14_RS04210 (839217) 839217..841193 - 1977 WP_223571364.1 glycogen debranching protein GlgX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T213429 WP_000277490.1 NZ_CP081791:836552-836836 [Escherichia coli]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T213429 NZ_CP107720:769652-769948 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT213429 WP_000124732.1 NZ_CP081791:836317-836559 [Escherichia coli]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT213429 NZ_CP107720:769950-770345 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References