Detailed information of TA system TA213411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4338677..4339272
• Replicon: chromosome
• Accession: NZ_CP081782
• Organism: Escherichia coli strain 0H26

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: J6O44_RS21285
• Protein ID: WP_000239581.1
• Coordinates: 4338677..4339027 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: J6O44_RS21290
• Protein ID: WP_001223213.1
• Coordinates: 4339021..4339272 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O44_RS21265 (4334126)	4334126..4335148	-	1023	WP_001548970.1	ABC transporter permease	-
J6O44_RS21270 (4335162)	4335162..4336664	-	1503	WP_001095667.1	sugar ABC transporter ATP-binding protein	-
J6O44_RS21275 (4336802)	4336802..4337758	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
J6O44_RS21280 (4338068)	4338068..4338598	+	531	WP_000055072.1	inorganic diphosphatase	-
J6O44_RS21285 (4338677)	4338677..4339027	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
J6O44_RS21290 (4339021)	4339021..4339272	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
J6O44_RS21295 (4339484)	4339484..4339825	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
J6O44_RS21300 (4339828)	4339828..4343607	-	3780	WP_001548968.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T213411 WP_000239581.1 NZ_CP081782:c4339027-4338677 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T213411 NZ_CP107611:c5242-4886 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT213411 WP_001223213.1 NZ_CP081782:c4339272-4339021 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT213411 NZ_CP107611:c4893-4591 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7