Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3902451..3903130 Replicon chromosome
Accession NZ_CP081782
Organism Escherichia coli strain 0H26

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag J6O44_RS19115 Protein ID WP_000854680.1
Coordinates 3902789..3903130 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EWR7
Locus tag J6O44_RS19110 Protein ID WP_000070396.1
Coordinates 3902451..3902768 (+) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O44_RS19065 (3897889) 3897889..3898710 + 822 WP_000197388.1 DUF932 domain-containing protein -
J6O44_RS19070 (3898927) 3898927..3899628 + 702 WP_000189411.1 WYL domain-containing protein -
J6O44_RS19075 (3899669) 3899669..3899905 + 237 WP_001144031.1 protein YpjK -
J6O44_RS19080 (3899905) 3899905..3900348 + 444 WP_001547764.1 lipoprotein YafY -
J6O44_RS19085 (3900371) 3900371..3900838 + 468 WP_001547765.1 protein YkfB -
J6O44_RS19090 (3900915) 3900915..3901154 + 240 WP_000194654.1 DUF905 family protein -
J6O44_RS19095 (3901252) 3901252..3901710 + 459 WP_001548150.1 antirestriction protein -
J6O44_RS19100 (3901726) 3901726..3902202 + 477 WP_000811693.1 RadC family protein -
J6O44_RS19105 (3902211) 3902211..3902432 + 222 WP_000691994.1 DUF987 domain-containing protein -
J6O44_RS19110 (3902451) 3902451..3902768 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
J6O44_RS19115 (3902789) 3902789..3903130 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
J6O44_RS19120 (3903951) 3903951..3905417 - 1467 WP_000723924.1 hypothetical protein -
J6O44_RS19125 (3905733) 3905733..3906122 - 390 WP_223596848.1 hypothetical protein -
J6O44_RS19130 (3906366) 3906366..3906452 - 87 Protein_3756 capsid protein -
J6O44_RS19135 (3906657) 3906657..3907430 + 774 WP_000355484.1 hypothetical protein -
J6O44_RS19140 (3907491) 3907491..3908045 - 555 WP_000905043.1 site-specific DNA recombinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gmhA/lpcA / IlpA 3846786..3996553 149767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(6-104)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T213408 WP_000854680.1 NZ_CP081782:3902789-3903130 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T213408 NZ_CP107609:c19107-18751 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11982.62 Da        Isoelectric Point: 7.0270

>AT213408 WP_000070396.1 NZ_CP081782:3902451-3902768 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT213408 NZ_CP107609:c18758-18456 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1FHS4


Antitoxin

Source ID Structure
AlphaFold DB S1EWR7

References